Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 4/20 | 0.45 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.45 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.43 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | BMP1 | P13497 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7344824 | 0.87 | L3MBTL1 (0.47) | KCNQ2TDP1L3MBTL1MAPTGAA | |
| SCHEMBL23193598 | 0.82 | ESR1 (0.47) | L3MBTL1MAPTSLC6A4ESR1ALDH1A1 | |
| SCHEMBL7345230 | 0.80 | AKR1C3 (0.46) | AKR1C3AKR1C2AKR1C1PTGS1 | |
| SCHEMBL27146207 | 0.79 | AKR1C3 (0.54) | AKR1C3AKR1C2AKR1C1PTGS1KCNQ2 | |
| SCHEMBL7353801 | 0.78 | AKR1C3 (0.43) | AKR1C3AKR1C2AKR1C1PTGS1KCNQ2 | |
| SCHEMBL7351298 | 0.78 | GAA (0.52) | CYP1A2MAPTALDH1A1GAASMN1; SMN2 | |
| SCHEMBL11210301 | 0.77 | LMNA (0.48) | AKR1C3AKR1C2AKR1C1PTGS1TDP1 | |
| SCHEMBL14941251 | 0.77 | ESR1 (0.49) | AKR1C3AKR1C2AKR1C1PTGS1CYP1A2 | |
| SCHEMBL28580616 | 0.77 | AKR1C3 (0.53) | AKR1C3AKR1C2AKR1C1PTGS1KCNQ2 | |
| SCHEMBL27996773 | 0.75 | AKR1C3 (0.50) | AKR1C3AKR1C2AKR1C1PTGS1KCNQ2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663416-A | ENZYME INHIBITORS AS ANTIINFLAMMATORY AGENTS OR DERMATITIS TREATMENT | CORTECH INC. | 1997-09-02 | — | — | US | disclosed |
| US-5214191-A | OXIDANT SENSITIVE AND INSENSITIVE AROMATIC ESTERS AS INHIBITORS OF HUMAN NEUTROPHIL ELASTASE | CORTECH, INC. (US) | 1993-05-25 | — | — | US | disclosed |
| EP-0465802-A1 | Oxidant sensitive and insensitive aromatic esters as inhibitors of human neutrophil elastase | CORTECH, INC. (US) | 1992-01-15 | — | — | EP | disclosed |