Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pivalate SCHEMBL8129979 | 0.92 | MEN1 (0.48) | L3MBTL1TDP1MEN1KMT2ALMNA | |
| SCHEMBL19182818 | 0.88 | L3MBTL1 (0.56) | L3MBTL1TDP1MEN1KMT2ALMNA | |
| SCHEMBL155788 | 0.88 | L3MBTL1 (0.56) | L3MBTL1TDP1MEN1KMT2ALMNA | |
| Formaldehyde SCHEMBL27761906 | 0.84 | L3MBTL1 (0.53) | L3MBTL1TDP1MEN1KMT2ALMNA | |
| SCHEMBL7344824 | 0.81 | L3MBTL1 (0.47) | L3MBTL1TDP1MEN1KMT2ALMNA | |
| SCHEMBL28465915 | 0.78 | KDM4E (0.46) | L3MBTL1TDP1MEN1KMT2ALMNA | |
| SCHEMBL28465913 | 0.78 | KDM4E (0.46) | L3MBTL1TDP1MEN1KMT2ALMNA | |
| SCHEMBL14941251 | 0.76 | ESR1 (0.49) | TDP1LMNAHSD17B10MAPTKCNQ2 | |
| SCHEMBL11210301 | 0.76 | LMNA (0.48) | L3MBTL1TDP1MEN1KMT2ALMNA | |
| 1-Hexanol SCHEMBL28322313 | 0.76 | L3MBTL1 (0.45) | L3MBTL1TDP1HTTKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663416-A | ENZYME INHIBITORS AS ANTIINFLAMMATORY AGENTS OR DERMATITIS TREATMENT | CORTECH INC. | 1997-09-02 | — | — | US | disclosed |
| US-5214191-A | OXIDANT SENSITIVE AND INSENSITIVE AROMATIC ESTERS AS INHIBITORS OF HUMAN NEUTROPHIL ELASTASE | CORTECH, INC. (US) | 1993-05-25 | — | — | US | disclosed |
| EP-0465802-A1 | Oxidant sensitive and insensitive aromatic esters as inhibitors of human neutrophil elastase | CORTECH, INC. (US) | 1992-01-15 | — | — | EP | disclosed |