Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | APEX1 | P27695 | 1/20 | 0.48 |
| ▸ | FABP4 | P15090 | 2/20 | 0.47 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | PNP | P00491 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7336981 | 0.86 | APEX1 (0.63) | KDM4EHSD17B10MAPK1APEX1FABP4 | |
| SCHEMBL4185101 | 0.83 | APEX1 (0.55) | KDM4EHSD17B10MAPK1APEX1FABP4 | |
| SCHEMBL411981 | 0.79 | APEX1 (0.54) | KDM4EHSD17B10MAPK1APEX1FABP4 | |
| SCHEMBL6520401 | 0.79 | APEX1 (0.78) | KDM4EHSD17B10MAPK1APEX1FABP4 | |
| SCHEMBL11234475 | 0.76 | MGLL (0.36) | MAPK1LMNAALDH1A1PTGS1PTGS2 | |
| SCHEMBL14645141 | 0.76 | MGLL (0.36) | MAPK1LMNAALDH1A1PTGS1PTGS2 | |
| SCHEMBL29251517 | 0.74 | APEX1 (0.62) | KDM4EHSD17B10MAPK1APEX1FABP4 | |
| SCHEMBL25465028 | 0.73 | PTGS1 (0.53) | APEX1FABP4FABP5LMNASLC22A6 | |
| SCHEMBL3771053 | 0.72 | FABP4 (0.46) | KDM4EHSD17B10MAPK1APEX1FABP4 | |
| SCHEMBL30976974 | 0.72 | APEX1 (0.47) | KDM4EHSD17B10MAPK1APEX1FABP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4307094-A | ANTIHYPERTENSIVE AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1981-12-22 | — | — | US | disclosed |