Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6525042 | 0.84 | POLB (0.40) | POLBKDM4EMAPTALDH1A1HSD17B10 | |
| SCHEMBL29251519 | 0.74 | POLB (0.36) | POLBKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL17371773 | 0.74 | POLB (0.42) | POLBKDM4EMAPTALDH1A1GAA | |
| SCHEMBL7336986 | 0.71 | KDM4E (0.45) | KDM4EMAPTALDH1A1HCRTR1GAA | |
| SCHEMBL27801894 | 0.71 | POLB (0.59) | POLBKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL9432792 | 0.69 | POLB (0.62) | POLBKDM4EALDH1A1HPGD | |
| SCHEMBL6937699 | 0.67 | ALDH1A1 (0.40) | POLBKDM4EMAPTALDH1A1GAA | |
| SCHEMBL964946 | 0.67 | DNMT1 (0.44) | POLBKDM4EMAPTALDH1A1GAA | |
| SCHEMBL698898 | 0.67 | ALDH1A1 (0.56) | POLBMAPTALDH1A1GAAMEN1 | |
| SCHEMBL7149835 | 0.66 | POLB (0.64) | POLBKDM4EMAPTALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4307094-A | ANTIHYPERTENSIVE AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1981-12-22 | — | — | US | disclosed |