Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | FABP4 | P15090 | 2/20 | 0.43 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.43 |
| ▸ | FABP3 | P05413 | 1/20 | 0.43 |
| ▸ | TSPO | P30536 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27830151 | 0.84 | POLB (0.49) | POLBKDM4EALDH1A1MAPTFABP4 | |
| SCHEMBL15822263 | 0.83 | POLB (0.49) | POLBKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9432792 | 0.83 | POLB (0.62) | POLBKDM4EALDH1A1HPGD | |
| SCHEMBL13682967 | 0.82 | FNTA (0.55) | POLBKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL7240590 | 0.82 | POLB (0.54) | POLBKDM4EALDH1A1HSD17B10KMT2A | |
| SCHEMBL14438995 | 0.81 | POLB (0.47) | POLB | |
| SCHEMBL7238867 | 0.80 | POLB (0.58) | POLBKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL2798839 | 0.80 | POLB (0.52) | POLBALDH1A1L3MBTL1MAPT | |
| SCHEMBL10673575 | 0.79 | MAPK8 (0.54) | POLBKDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL7654816 | 0.78 | PGR (0.55) | POLBKDM4EALDH1A1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6525043-B2 | Bicyclic or tricyclic ketones, oximes, amine oxides or amines are used as calcium or potassium channel modulators | NEUROSEARCH A/S (DK) | 2003-02-25 | — | — | US | claimed |
| US-20020065266-A1 | Use of ion channel modulating agents | NEUROSEARCH A/S (DK) | 2002-05-30 | — | — | US | claimed |
| EP-1187610-A2 | USE OF ION CHANNEL MODULATING AGENTS | NEUROSEARCH A/S (DK) | 2002-03-20 | — | — | EP | claimed |
| WO-2000069794-A2 | USE OF CALCIUM-ACTIVATED POTASSIUM CHANNEL-MODULATING AGENTS | NEUROSEARCH A/S (DK) | 2000-11-23 | — | — | WO | claimed |
| CN-1263092-A | Carboxylic compound and its preparation method and application | LANZHOU CHEM PHYS INST (CN) | 2000-08-16 | — | — | CN | claimed |
| US-6525043-B2 | Bicyclic or tricyclic ketones, oximes, amine oxides or amines are used as calcium or potassium channel modulators | NEUROSEARCH A/S (DK) | 2003-02-25 | — | — | US | disclosed |
| US-20020065266-A1 | Use of ion channel modulating agents | NEUROSEARCH A/S (DK) | 2002-05-30 | — | — | US | disclosed |
| EP-1187610-A2 | USE OF ION CHANNEL MODULATING AGENTS | NEUROSEARCH A/S (DK) | 2002-03-20 | — | — | EP | disclosed |
| WO-2000069794-A2 | USE OF CALCIUM-ACTIVATED POTASSIUM CHANNEL-MODULATING AGENTS | NEUROSEARCH A/S (DK) | 2000-11-23 | — | — | WO | disclosed |
| CN-1263092-A | Carboxylic compound and its preparation method and application | LANZHOU CHEM PHYS INST (CN) | 2000-08-16 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020065266-A1 | Use of ion channel modulating agents | KCNN3, KCNN1, KCNN2 | POLB 4836/4885KDM4E 1513/4885ALDH1A1 4532/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.