Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | PDK1 | Q15118 | 6/20 | 0.53 |
| ▸ | PDK2 | Q15119 | 6/20 | 0.53 |
| ▸ | PDK3 | Q15120 | 6/20 | 0.53 |
| ▸ | PDK4 | Q16654 | 6/20 | 0.53 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.52 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13776668 | 0.82 | PDK1 (0.61) | MEN1KMT2ATSHRPDK1PDK2 | |
| SCHEMBL7351015 | 0.82 | MEN1 (0.61) | MEN1KMT2ATSHRPDK1PDK2 | |
| SCHEMBL13776188 | 0.80 | MEN1 (0.69) | MEN1KMT2ATSHRPDK1PDK2 | |
| SCHEMBL13776259 | 0.79 | MEN1 (0.58) | MEN1KMT2ATSHRPDK1PDK2 | |
| SCHEMBL6964138 | 0.76 | L3MBTL1 (0.60) | MEN1KMT2ANR3C2L3MBTL1ALDH1A1 | |
| SCHEMBL13776257 | 0.76 | KMT2A (0.55) | MEN1KMT2ATSHRPDK1PDK2 | |
| SCHEMBL7354608 | 0.76 | MEN1 (0.55) | MEN1KMT2ATSHRPDK1PDK2 | |
| SCHEMBL7356846 | 0.76 | L3MBTL1 (0.47) | MEN1KMT2AL3MBTL1ALDH1A1LMNA | |
| Lithium Ion SCHEMBL22092468 | 0.74 | TSHR (0.59) | MEN1KMT2ATSHRPDK1PDK2 | |
| Lithium Ion SCHEMBL30437889 | 0.74 | TSHR (0.59) | MEN1KMT2ATSHRPDK1PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5985869-A | USEFUL AS VASODILATORS, HYPOTENSIVE AGENTS, WATER DIURETICS, PLATELET AGGLUTINATION INHIBITORS | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1999-11-16 | — | — | US | disclosed |
| US-5753677-A | Benzoheterocyclic compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1998-05-19 | — | — | US | disclosed |
| US-5559230-A | VASOPRESSIN ANTAGONISTS, QUINOLINES, BENZAZEPINES, VASODILATION, HYPOTENSIVE AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-09-24 | — | — | US | disclosed |
| EP-0450097-B1 | BENZOHETEROCYCLIC COMPOUNDS | OTSUKA PHARMA CO LTD (JP) | 1996-04-24 | — | — | EP | disclosed |
| EP-0450097-A1 | BENZOHETEROCYCLIC COMPOUNDS. | OTSUKA PHARMA CO LTD (JP) | 1991-10-09 | — | — | EP | disclosed |
| WO-1991005549-A1 | BENZOHETEROCYCLIC COMPOUNDS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-05-02 | — | — | WO | disclosed |