Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 11/20 | 0.51 |
| ▸ | EDNRB | P24530 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7334893 | 0.93 | EDNRA (0.51) | EDNRAEDNRBKDM4EALDH1A1HPGD | |
| SCHEMBL7071144 | 0.88 | EDNRA (0.50) | EDNRAEDNRB | |
| SCHEMBL7827271 | 0.87 | EDNRA (0.47) | EDNRAEDNRBKDM4EALDH1A1HPGD | |
| SCHEMBL7336545 | 0.86 | EDNRA (0.51) | EDNRAEDNRB | |
| SCHEMBL7829178 | 0.86 | EDNRA (0.44) | EDNRAEDNRBKDM4EALDH1A1HPGD | |
| SCHEMBL7069874 | 0.84 | EDNRA (0.56) | EDNRAEDNRBALDH1A1 | |
| SCHEMBL7336214 | 0.83 | EDNRA (0.42) | EDNRAEDNRBKDM4EALDH1A1HPGD | |
| SCHEMBL7065399 | 0.83 | EDNRB (0.55) | EDNRAEDNRBKDM4EALDH1A1HPGD | |
| SCHEMBL6541874 | 0.81 | EDNRA (0.53) | EDNRAEDNRBKDM4EALDH1A1HPGD | |
| SCHEMBL7339542 | 0.77 | EDNRA (0.42) | EDNRAEDNRBKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0811001-B1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER LAMBERT CO (US) | 2001-10-31 | — | — | EP | claimed |
| WO-1996026195-A1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1996-08-29 | — | — | WO | claimed |