Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 10/20 | 0.47 |
| ▸ | EDNRB | P24530 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7345193 | 0.87 | EDNRA (0.51) | EDNRAEDNRBKDM4EALDH1A1HPGD | |
| SCHEMBL7828674 | 0.87 | EDNRA (0.47) | EDNRAEDNRBNPC1RAB9A | |
| SCHEMBL6541879 | 0.81 | EDNRA (0.41) | EDNRAEDNRBKDM4EALDH1A1HPGD | |
| SCHEMBL7334893 | 0.80 | EDNRA (0.51) | EDNRAEDNRBKDM4EALDH1A1HPGD | |
| SCHEMBL6542057 | 0.78 | EDNRA (0.51) | EDNRAEDNRBALDH1A1NPC1LMNA | |
| SCHEMBL7829192 | 0.76 | EDNRB (0.51) | EDNRAEDNRBKDM4EALDH1A1HPGD | |
| SCHEMBL7831616 | 0.76 | EDNRB (0.49) | EDNRAEDNRBALDH1A1MAPT | |
| SCHEMBL6541829 | 0.75 | EDNRA (0.43) | EDNRAEDNRBKDM4EALDH1A1HPGD | |
| SCHEMBL6541685 | 0.75 | EDNRA (0.47) | EDNRAEDNRBKDM4EALDH1A1HPGD | |
| SCHEMBL6542600 | 0.75 | EDNRA (0.44) | EDNRAEDNRBKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0811001-B1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER LAMBERT CO (US) | 2001-10-31 | — | — | EP | claimed |