Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.31 |
| ▸ | CDK4 | P11802 | 1/20 | 0.31 |
| ▸ | CCND1 | P24385 | 1/20 | 0.31 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.31 |
| ▸ | NCF1 | P14598 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7270869 | 0.67 | NCF1 (0.41) | ADORA1HDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL423324 | 0.65 | CYP1A2 (0.59) | NCF1 | |
| SCHEMBL30081479 | 0.64 | BACE1 (0.53) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL727654 | 0.64 | BACE1 (0.53) | ADORA1HDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL19330216 | 0.64 | HTR3A (0.45) | ADORA1HDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL29768705 | 0.64 | ESR1 (0.50) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL7270843 | 0.64 | APP (0.41) | ADORA1HDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL1238150 | 0.64 | ESR1 (0.50) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL21698711 | 0.64 | KDM4E (0.58) | LMNAHDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL16751340 | 0.63 | PDE10A (0.46) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5141931-A | 5-Quinolinylpyridinones, cardiotonic compositions and methods | STERLING WINTHROP INC. (US) | 1992-08-25 | — | — | US | disclosed |