Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.52 |
| ▸ | PDE2A | O00408 | 3/20 | 0.52 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 2/20 | 0.43 |
| ▸ | CTSD | P07339 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 2/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | MAT2A | P31153 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15730144 | 0.82 | POLB (0.47) | BACE1CTSDNPC1POLBRAB9A | |
| SCHEMBL15730171 | 0.81 | NPC1 (0.67) | NPC1POLBRAB9AABL1TGFBR1 | |
| SCHEMBL15730178 | 0.80 | CYP11B2 (0.56) | NPC1RAB9AABL1 | |
| SCHEMBL15730261 | 0.76 | CYP2A6 (0.54) | PDE10APDE2AMKNK1MKNK2JAK2 | |
| SCHEMBL16805031 | 0.76 | ABL1 (0.52) | ADORA1NPC1POLBRAB9AABL1 | |
| SCHEMBL7264558 | 0.74 | CYP11B2 (0.64) | PDE10APDE2AABL1MKNK1MKNK2 | |
| SCHEMBL16573997 | 0.74 | PDGFRB (0.46) | PDE10APDE2AADORA1BACE1NPC1 | |
| SCHEMBL12695592 | 0.74 | BACE1 (0.57) | ADORA1BACE1NPC1RAB9APDGFRB | |
| SCHEMBL15730608 | 0.74 | ALDH1A1 (0.58) | NPC1POLBRAB9AABL1TGFBR1 | |
| SCHEMBL7270915 | 0.73 | ADORA1 (0.42) | PDE10APDE2AADORA1NPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5141931-A | 5-Quinolinylpyridinones, cardiotonic compositions and methods | STERLING WINTHROP INC. (US) | 1992-08-25 | — | — | US | disclosed |