Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 4/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MMP13 | P45452 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | MMP7 | P09237 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.30 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7052704 | 0.87 | SMN1; SMN2 (0.33) | CHRM3SMN1; SMN2ALDH1A1MMP13MEN1 | |
| SCHEMBL7053097 | 0.81 | MMP13 (0.34) | ALDH1A1MMP13MEN1KMT2AMMP1 | |
| SCHEMBL7059237 | 0.81 | MMP1 (0.36) | MMP13MEN1KMT2AMMP1MMP3 | |
| SCHEMBL7055311 | 0.80 | PSEN1 (0.34) | ALDH1A1MMP13MEN1KMT2AMMP1 | |
| SCHEMBL7346041 | 0.79 | HTT (0.38) | SMN1; SMN2ALDH1A1MMP13MEN1KMT2A | |
| SCHEMBL7058134 | 0.78 | MMP13 (0.42) | MMP13MMP1MMP3MMP7MMP9 | |
| SCHEMBL7060656 | 0.75 | MMP13 (0.39) | SMN1; SMN2ALDH1A1MMP13MMP1MMP3 | |
| SCHEMBL7058988 | 0.74 | PREP (0.42) | SMN1; SMN2ALDH1A1KMT2AL3MBTL1MAPT | |
| SCHEMBL7561573 | 0.73 | C3AR1 (0.37) | MMP13MMP1MMP3MMP7MMP9 | |
| SCHEMBL7054549 | 0.73 | HCRTR1 (0.37) | SMN1; SMN2ALDH1A1MMP13KMT2AMMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948489-A1 | PIPERAZINE COMPOUNDS AS INHIBITORS OF MMP OR TNF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998027069-A1 | PIPERAZINE COMPOUNDS AS INHIBITORS OF MMP OR TNF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-06-25 | — | — | WO | disclosed |