Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 1/20 | 0.42 |
| ▸ | KDM4A | O75164 | 1/20 | 0.40 |
| ▸ | NQO2 | P16083 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | MIF | P14174 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7347910 | 0.90 | KCNA5 (0.42) | KCNA5KDM4ANQO2LMNAPOLB | |
| SCHEMBL7354883 | 0.82 | KCNA5 (0.43) | KCNA5KDM4ANQO2LMNAPOLB | |
| SCHEMBL25961089 | 0.75 | EGFR (0.43) | KCNA5LMNAADRA1AADRA1BEGFR | |
| SCHEMBL31617814 | 0.75 | ALDH1A1 (0.44) | LMNAHTTKMT2AADRA1AADRA1B | |
| SCHEMBL7675373 | 0.75 | ALDH1A1 (0.42) | KCNA5LMNAMEN1NPC1HTT | |
| SCHEMBL2158784 | 0.73 | KCNA5 (0.55) | KCNA5KDM4ALMNAKMT2ANAMPT | |
| SCHEMBL951581 | 0.73 | TSHR (0.46) | LMNAHTTADRA1AADRA1BEGFR | |
| SCHEMBL26673798 | 0.72 | IDO1 (0.46) | KCNA5NQO2LMNANPC1HTT | |
| SCHEMBL7345283 | 0.72 | PPARA (0.40) | KCNA5SYKIDO1CTSSCTSL | |
| SCHEMBL3499475 | 0.72 | LMNA (0.44) | KCNA5LMNAMEN1NPC1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5356888-A | Elastase inhibitors | FARMITALIA CARLO ERBA (IT) | 1994-10-18 | — | — | US | disclosed |
| EP-0378604-B1 | 1,1-DIOXO-CEPHEM-4-CARBOTHIOLIC ACID DERIVATIVES | ERBA CARLO SPA (IT) | 1994-03-02 | — | — | EP | disclosed |
| EP-0378604-A1 | 1,1-DIOXO-CEPHEM-4-CARBOTHIOLIC ACID DERIVATIVES. | ERBA CARLO SPA (IT) | 1990-07-25 | — | — | EP | disclosed |
| WO-1989010926-A1 | 1,1-DIOXO-CEPHEM-4-CARBOTHIOLIC ACID DERIVATIVES | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-11-16 | — | — | WO | disclosed |