Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 4/20 | 0.34 |
| ▸ | MAOA | P21397 | 4/20 | 0.34 |
| ▸ | MAOB | P27338 | 4/20 | 0.34 |
| ▸ | KDM1B | Q8NB78 | 4/20 | 0.34 |
| ▸ | RCOR1 | Q9UKL0 | 4/20 | 0.34 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7346193 | 0.70 | HDAC6 (0.41) | GAAHDAC8ALDH1A1LMNAMAPT | |
| SCHEMBL7345333 | 0.69 | ATM (0.61) | GAAALDH1A1LMNA | |
| SCHEMBL7348711 | 0.69 | HDAC6 (0.45) | HDAC3HDAC8HDAC1HDAC2HDAC6 | |
| SCHEMBL7345340 | 0.68 | CHRM2 (0.40) | OPRK1GAAALDH1A1LMNAMAPT | |
| SCHEMBL7343435 | 0.67 | CACNA2D1 (0.46) | GAAALDH1A1LMNAHDAC6 | |
| SCHEMBL7348298 | 0.67 | POLB (0.45) | ALDH1A1LMNAMAPT | |
| Oxalic Acid SCHEMBL9282086 | 0.66 | ALDH1A1 (0.45) | GAAALDH1A1LMNA | |
| SCHEMBL24835247 | 0.65 | P2RX7 (0.38) | — | |
| SCHEMBL7481751 | 0.64 | ALDH1A1 (0.55) | GAAALDH1A1LMNAMAPTHDAC1 | |
| SCHEMBL6119612 | 0.64 | SRD5A2 (0.48) | ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0658157-A1 | DIARYL PIPERAZINOACETAMIDE COMPOUNDS AS ANTIMUSCARINIC AGENTS | MERRELL PHARMACEUTICALS INC. (US) | 1995-06-21 | — | — | EP | disclosed |
| WO-1994005648-A1 | DIARYL PIPERAZINOACETAMIDE COMPOUNDS AS ANTIMUSCARINIC AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-03-17 | — | — | WO | disclosed |
| EP-0585500-A1 | Diaryl piperazineacetamides as antimuscarinic agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-03-09 | — | — | EP | disclosed |