Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | USP2 | O75604 | 2/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | AVPR2 | P30518 | 6/20 | 0.49 |
| ▸ | AVPR1A | P37288 | 5/20 | 0.49 |
| ▸ | OXTR | P30559 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6990464 | 0.96 | ALDH1A1 (0.52) | ALDH1A1LMNAUSP2PDE4BPDE4D | |
| SCHEMBL7352575 | 0.93 | ALDH1A1 (0.56) | ALDH1A1LMNAUSP2TP53TSHR | |
| SCHEMBL7351070 | 0.86 | AVPR2 (0.67) | ALDH1A1LMNAUSP2PDE4BPDE4D | |
| SCHEMBL6959618 | 0.85 | AVPR2 (0.68) | ALDH1A1LMNAUSP2PDE4BPDE4D | |
| SCHEMBL7352245 | 0.84 | MEN1 (0.50) | ALDH1A1LMNAUSP2PDE4BPDE4D | |
| SCHEMBL6968459 | 0.84 | BCHE (0.56) | ALDH1A1LMNAUSP2PDE4BPDE4D | |
| SCHEMBL7352139 | 0.84 | AVPR2 (0.52) | ALDH1A1LMNAUSP2MAPTAVPR2 | |
| SCHEMBL6961949 | 0.82 | MAPT (0.48) | ALDH1A1LMNAUSP2PDE4BPDE4D | |
| SCHEMBL6961951 | 0.82 | MAPT (0.48) | ALDH1A1LMNAUSP2PDE4BPDE4D | |
| SCHEMBL7347078 | 0.82 | AVPR2 (0.71) | ALDH1A1LMNAUSP2TP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5985869-A | USEFUL AS VASODILATORS, HYPOTENSIVE AGENTS, WATER DIURETICS, PLATELET AGGLUTINATION INHIBITORS | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1999-11-16 | — | — | US | disclosed |
| US-5753677-A | Benzoheterocyclic compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1998-05-19 | — | — | US | disclosed |
| US-5559230-A | VASOPRESSIN ANTAGONISTS, QUINOLINES, BENZAZEPINES, VASODILATION, HYPOTENSIVE AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-09-24 | — | — | US | disclosed |
| EP-0450097-B1 | BENZOHETEROCYCLIC COMPOUNDS | OTSUKA PHARMA CO LTD (JP) | 1996-04-24 | — | — | EP | disclosed |
| WO-1991005549-A1 | BENZOHETEROCYCLIC COMPOUNDS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-05-02 | — | — | WO | disclosed |