Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.48 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7345718 | 0.96 | ALDH1A1 (0.49) | ALDH1A1MAPTMEN1USP2LMNA | |
| SCHEMBL7352575 | 0.94 | ALDH1A1 (0.56) | ALDH1A1MAPTUSP2LMNAHTT | |
| SCHEMBL7352245 | 0.88 | MEN1 (0.50) | ALDH1A1MAPTMEN1USP2LMNA | |
| SCHEMBL6961949 | 0.86 | MAPT (0.48) | ALDH1A1MAPTMEN1USP2LMNA | |
| SCHEMBL6961951 | 0.86 | MAPT (0.48) | ALDH1A1MAPTMEN1USP2LMNA | |
| SCHEMBL6968459 | 0.85 | BCHE (0.56) | ALDH1A1MAPTMEN1USP2LMNA | |
| SCHEMBL7352388 | 0.85 | ALDH1A1 (0.69) | ALDH1A1MAPTMEN1USP2LMNA | |
| SCHEMBL1495885 | 0.84 | ALDH1A1 (0.58) | ALDH1A1MEN1USP2LMNAKMT2A | |
| SCHEMBL7346878 | 0.83 | ALDH1A1 (0.49) | ALDH1A1MAPTMEN1USP2LMNA | |
| SCHEMBL7346895 | 0.83 | ALDH1A1 (0.49) | ALDH1A1MAPTMEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 74 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10472375-B2 | 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative | PULMOCIDE LIMITED (GB) | 2019-11-12 | — | — | US | disclosed |
| US-10472375-B2 | 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative | PULMOCIDE LIMITED (GB) | 2019-11-12 | — | — | US | disclosed |
| US-20190202841-A1 | Novel 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative | PULMOCIDE LTD (GB) | 2019-07-04 | — | — | US | disclosed |
| US-20190202841-A1 | Novel 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative | PULMOCIDE LTD (GB) | 2019-07-04 | — | — | US | disclosed |
| EP-3204389-B1 | NOVEL 5,6-DIHYDRO-4H-BENZO[B]THIENO-[2,3-D]AZEPINE DERIVATIVE | PULMOCIDE LTD (GB) | 2019-06-26 | — | — | EP | disclosed |
| EP-3204389-B1 | NOVEL 5,6-DIHYDRO-4H-BENZO[B]THIENO-[2,3-D]AZEPINE DERIVATIVE | PULMOCIDE LTD (GB) | 2019-06-26 | — | — | EP | disclosed |
| US-10273249-B2 | 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative | PULMOCIDE LIMITED (GB) | 2019-04-30 | — | — | US | disclosed |
| US-10273249-B2 | 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative | PULMOCIDE LIMITED (GB) | 2019-04-30 | — | — | US | disclosed |
| US-10189863-B2 | 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivatives | PULMOCIDE LIMITED (GB) | 2019-01-29 | — | — | US | disclosed |
| US-10189863-B2 | 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivatives | PULMOCIDE LIMITED (GB) | 2019-01-29 | — | — | US | disclosed |
| WO-1997047624-A1 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID COMPANY (US) | 1997-12-18 | — | — | WO | disclosed |
| US-5693635-A | TREATMENT OF DISEASES CHARACTERIZED BY EXCESS RENAL ABSORPTION OF WATER; CONGESTIVE HEART FAILURE, NEPHROTIC SYNDROME | AMERICAN CYANAMID COMPANY (US) | 1997-12-02 | — | — | US | disclosed |
| US-5686445-A | Pyridobenzoxazepine and pyridobenzothiazepine vasopressin antagonists | AMERICAN CYANAMID COMPANY (US) | 1997-11-11 | — | — | US | disclosed |
| US-5559230-A | VASOPRESSIN ANTAGONISTS, QUINOLINES, BENZAZEPINES, VASODILATION, HYPOTENSIVE AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-09-24 | — | — | US | disclosed |
| EP-0709386-A1 | FUSED BENZAZEPINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1996-05-01 | — | — | EP | disclosed |
| US-5512563-A | TREATING DISEASES CAUSED BY EXCESS RENAL REABSORPTION OF WATER | AMERICAN CYANAMID COMPANY (US) | 1996-04-30 | — | — | US | disclosed |
| EP-0450097-B1 | BENZOHETEROCYCLIC COMPOUNDS | OTSUKA PHARMA CO LTD (JP) | 1996-04-24 | — | — | EP | disclosed |
| EP-0640592-A1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID COMPANY (US) | 1995-03-01 | — | — | EP | disclosed |
| EP-0450097-A1 | BENZOHETEROCYCLIC COMPOUNDS. | OTSUKA PHARMA CO LTD (JP) | 1991-10-09 | — | — | EP | disclosed |
| WO-1991005549-A1 | BENZOHETEROCYCLIC COMPOUNDS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-05-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10189863-B2 | 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivatives | AZI2, HRH4, ZC3HAV1 | ALDH1A1 1873/4885MAPT 4340/4885MEN1 4612/4885 |
| US-10472375-B2 | 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative | AZI2, DHX15, HRH4 | ALDH1A1 843/4885MAPT 4485/4885MEN1 4276/4885 |
| US-20190202841-A1 | Novel 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative | IL5, ZC3HAV1, AZI2 | ALDH1A1 954/4885MAPT 4523/4885MEN1 4570/4885 |
| US-10273249-B2 | 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative | HYOU1, HRH1, ZC3HAV1 | ALDH1A1 410/4885MAPT 4580/4885MEN1 3993/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.