Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMA1 | P23946 | 1/20 | 0.43 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7026619 | 0.96 | CMA1 (0.46) | CMA1KCNJ1KCNH2GSK3AGSK3B | |
| SCHEMBL7343149 | 0.78 | SIGMAR1 (0.45) | CMA1GSK3AGSK3BGRM2SIGMAR1 | |
| SCHEMBL7345064 | 0.78 | SIGMAR1 (0.51) | SIGMAR1DRD4MAPTKDM4EALDH1A1 | |
| SCHEMBL7336969 | 0.76 | TSHR (0.33) | — | |
| SCHEMBL7106540 | 0.76 | CMA1 (0.41) | CMA1KCNJ1KCNH2GSK3AGSK3B | |
| SCHEMBL7337875 | 0.76 | APLNR (0.47) | MAPTKDM4EALDH1A1 | |
| SCHEMBL7343232 | 0.76 | BCHE (0.42) | CMA1SIGMAR1MAPTKDM4EALDH1A1 | |
| SCHEMBL7339502 | 0.73 | KDM4E (0.46) | KDM4EALDH1A1ALOX15 | |
| SCHEMBL7025144 | 0.72 | SIGMAR1 (0.49) | CMA1GSK3AGSK3BGRM2SIGMAR1 | |
| SCHEMBL16136778 | 0.71 | CMA1 (0.47) | CMA1KCNJ1KCNH2GSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4358599-A | Synthesis of 4-amino-1,2-hydrocarbyl pyrazolidines via 4-nitro analogs | A. H. ROBINS COMPANY, INC. (US) | 1982-11-09 | — | — | US | disclosed |
| US-4309552-A | Synthesis of 4-nitro-1,2-hydrocarbyl pyrazolidines and process for preparation thereof | A. H. ROBINS COMPANY, INC. (US) | 1982-01-05 | — | — | US | disclosed |