Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 4/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7369085 | 0.90 | MAPK8 (0.53) | MAPK8ALDH1A1GAAPOLB | |
| SCHEMBL7373674 | 0.86 | MAPK8 (0.54) | MAPK8ALDH1A1GAAPOLB | |
| SCHEMBL6965251 | 0.83 | MAPK8 (0.66) | MAPK8ALDH1A1GAATDP1POLB | |
| SCHEMBL10073050 | 0.82 | MAPK8 (0.77) | MAPK8ALDH1A1POLB | |
| SCHEMBL4619023 | 0.81 | MAPK8 (0.66) | MAPK8ALDH1A1GAATDP1POLB | |
| SCHEMBL7366862 | 0.81 | MAPK8 (0.56) | MAPK8ALDH1A1GAAPOLB | |
| SCHEMBL7310026 | 0.80 | MAPK8 (1.00) | MAPK8ALDH1A1GAATDP1 | |
| SCHEMBL8568262 | 0.79 | ALDH1A1 (0.74) | MAPK8ALDH1A1GAATDP1POLB | |
| SCHEMBL5213184 | 0.79 | ALDH1A1 (1.00) | MAPK8ALDH1A1GAATDP1POLB | |
| SCHEMBL5717635 | 0.79 | ALDH1A1 (0.73) | MAPK8ALDH1A1GAATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0357316-B1 | ANTIDEPRESSANT N-SUBSTITUTED NICOTINAMIDE COMPOUNDS | PFIZER INC. (US) | 1993-04-14 | — | — | EP | disclosed |
| US-5057142-A | Herbicidal thiazolecarboxamide derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 1991-10-15 | — | — | US | disclosed |
| EP-0422470-A2 | Thiazolcarboxylic acid amide derivatives | BAYER AG (DE) | 1991-04-17 | — | — | EP | disclosed |
| EP-0357316-A1 | Antidepressant N-substituted nicotinamide compounds | PFIZER INC. (US) | 1990-03-07 | — | — | EP | disclosed |
| US-4861891-A | Antidepressant N-substituted nicotinamide compounds | PFIZER INC. (US) | 1989-08-29 | — | — | US | disclosed |
| US-4270946-A | N-Aryl,2-phenoxy nicotinamide compounds and the herbicidal use thereof | STAUFFER CHEMICAL COMPANY (US) | 1981-06-02 | — | — | US | disclosed |