Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.54 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7352468 | 0.84 | HTT (0.44) | TMEM97SIGMAR1HDAC3HDAC1HDAC2 | |
| SCHEMBL7351073 | 0.82 | HDAC3 (0.44) | TMEM97SIGMAR1HDAC3HDAC1HDAC2 | |
| SCHEMBL13083453 | 0.80 | KDM4E (0.49) | KMT2AMEN1MAPTL3MBTL1 | |
| SCHEMBL7347710 | 0.76 | KMT2A (0.49) | TMEM97SIGMAR1DGAT1HDAC3HDAC1 | |
| SCHEMBL7346997 | 0.76 | MEN1 (0.42) | HDAC3HDAC1HDAC2HDAC8NCOR2 | |
| SCHEMBL3280774 | 0.75 | TMEM97 (0.56) | TMEM97SIGMAR1DGAT1HDAC3HDAC1 | |
| SCHEMBL691531 | 0.73 | DGAT1 (0.61) | TMEM97SIGMAR1DGAT1NPC1KMT2A | |
| SCHEMBL29993519 | 0.73 | DGAT1 (0.61) | TMEM97SIGMAR1DGAT1NPC1KMT2A | |
| SCHEMBL3054837 | 0.72 | DGAT1 (0.56) | TMEM97SIGMAR1DGAT1NPC1PDPK1 | |
| SCHEMBL11900526 | 0.72 | DGAT1 (0.56) | TMEM97SIGMAR1DGAT1HTTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0972764-A1 | Aminoalcohols and aminoketones as CNS active agents | Universita Degli Studi di Firenze (IT) | 2000-01-19 | — | — | EP | claimed |
| EP-0972764-A1 | Aminoalcohols and aminoketones as CNS active agents | Universita Degli Studi di Firenze (IT) | 2000-01-19 | — | — | EP | disclosed |