SCHEMBL7345985

SCHEMBL7345985

Nc1ccc(OCCC=O)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 3/20 0.50
RAB9A P51151 2/20 0.48
NPC1 O15118 1/20 0.48
TSHR P16473 2/20 0.48
NFE2L2 Q16236 1/20 0.44
MAPT P10636 2/20 0.43
ALDH1A1 P00352 2/20 0.43
KMT2A Q03164 1/20 0.43
MAOB P27338 3/20 0.42
GAA P10253 1/20 0.42
MAOA P21397 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
APP P05067 5/20 0.42
LTA4H P09960 1/20 0.42
PTGS1 P23219 1/20 0.42
PTGS2 P35354 1/20 0.42
CYP3A4 P08684 1/20 0.41
ESR1 P03372 2/20 0.39
CYP19A1 P11511 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16672091 0.81 LTA4H (0.50) MAPTALDH1A1SMN1; SMN2L3MBTL1LTA4H
SCHEMBL12801865 0.80 KEAP1 (0.53) NFE2L2MAPTALDH1A1MAOBSMN1; SMN2
SCHEMBL9784265 0.79 TDP1 (0.64) TDP1RAB9ANPC1TSHRNFE2L2
SCHEMBL3482694 0.79 TDP1 (0.64) TDP1RAB9ANPC1TSHRNFE2L2
SCHEMBL5536818 0.79 DRD4 (0.49) RAB9ANPC1ALDH1A1MAOBSMN1; SMN2
SCHEMBL98740 0.79 DRD4 (0.47) MAPTALDH1A1KMT2AMAOBMAOA
SCHEMBL2562145 0.79 DRD2 (0.47) TDP1RAB9ANPC1TSHRALDH1A1
SCHEMBL7352176 0.79 NQO1 (0.58) TDP1TSHRMAPTALDH1A1SMN1; SMN2
SCHEMBL19043228 0.79 LTA4H (0.52) TSHRMAPTALDH1A1SMN1; SMN2LTA4H
SCHEMBL9415983 0.79 LTA4H (0.50) LTA4HPTGS1PTGS2ESR1CYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008031034-A2 THERAPEUTIC COMPOUNDS FOR DISEASES AND DISORDERS MYRIAD GENETICS, INC. (US) 2008-03-13 WO disclosed
US-5985869-A USEFUL AS VASODILATORS, HYPOTENSIVE AGENTS, WATER DIURETICS, PLATELET AGGLUTINATION INHIBITORS OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) 1999-11-16 US disclosed
US-5753677-A Benzoheterocyclic compounds OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1998-05-19 US disclosed
US-5559230-A VASOPRESSIN ANTAGONISTS, QUINOLINES, BENZAZEPINES, VASODILATION, HYPOTENSIVE AGENTS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1996-09-24 US disclosed
EP-0450097-B1 BENZOHETEROCYCLIC COMPOUNDS OTSUKA PHARMA CO LTD (JP) 1996-04-24 EP disclosed
EP-0602209-A1 OXYTOCIN ANTAGONIST OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1994-06-22 EP disclosed
WO-1994001113-A1 OXYTOCIN ANTAGONIST OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) 1994-01-20 WO disclosed
EP-0450097-A1 BENZOHETEROCYCLIC COMPOUNDS. OTSUKA PHARMA CO LTD (JP) 1991-10-09 EP disclosed
WO-1991005549-A1 BENZOHETEROCYCLIC COMPOUNDS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1991-05-02 WO disclosed