Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 11/20 | 0.37 |
| ▸ | ITGAV | P06756 | 11/20 | 0.37 |
| ▸ | ITGB6 | P18564 | 6/20 | 0.37 |
| ▸ | GPR139 | Q6DWJ6 | 4/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.36 |
| ▸ | ITGA5 | P08648 | 3/20 | 0.36 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.36 |
| ▸ | ITGB8 | P26012 | 1/20 | 0.36 |
| ▸ | ITGA8 | P53708 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7340345 | 0.90 | TP53 (0.39) | LMNAITGB3ITGAVGPR139TP53 | |
| SCHEMBL7341748 | 0.90 | TACR1 (0.41) | MEN1KMT2AITGB3ITGAVITGB6 | |
| SCHEMBL7344058 | 0.89 | GLA (0.41) | MEN1KMT2AKDM4ELMNAMAPT | |
| SCHEMBL7825718 | 0.89 | TP53 (0.47) | MEN1KMT2AITGB3ITGAVGPR139 | |
| SCHEMBL7345088 | 0.89 | ITGB3 (0.41) | MEN1KMT2AKDM4ELMNAMAPT | |
| SCHEMBL7339503 | 0.87 | KMT2A (0.42) | MEN1KMT2ALMNAMAPTITGB3 | |
| SCHEMBL7338364 | 0.87 | GPR139 (0.45) | MEN1KMT2AKDM4ELMNAMAPK1 | |
| SCHEMBL7341105 | 0.86 | CTSL (0.46) | MEN1KMT2AGPR139TP53 | |
| SCHEMBL7837425 | 0.86 | GPR139 (0.40) | MEN1KMT2ALMNAITGB3ITGAV | |
| SCHEMBL7339157 | 0.85 | TACR1 (0.44) | MEN1KMT2AMAPTITGB3ITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-B1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2001-07-18 | — | — | EP | claimed |
| EP-0850221-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1998-07-01 | — | — | EP | claimed |
| WO-1997008145-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-03-06 | — | — | WO | claimed |