Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 9/20 | 0.75 |
| ▸ | MMP1 | P03956 | 9/20 | 0.75 |
| ▸ | MMP9 | P14780 | 8/20 | 0.75 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.75 |
| ▸ | MMP2 | P08253 | 6/20 | 0.61 |
| ▸ | MMP3 | P08254 | 4/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CTRC | Q99895 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6928909 | 1.00 | MMP13 (0.75) | MMP13MMP1MMP9ADAM17MMP2 | |
| SCHEMBL6933212 | 0.94 | MMP13 (0.74) | MMP13MMP1MMP9ADAM17MMP2 | |
| SCHEMBL10419183 | 0.87 | MMP1 (0.58) | MMP13MMP1MMP9ADAM17MMP2 | |
| SCHEMBL6933028 | 0.87 | MMP13 (0.72) | MMP13MMP1MMP9ADAM17MMP2 | |
| SCHEMBL6933449 | 0.87 | MMP13 (0.72) | MMP13MMP1MMP9ADAM17MMP2 | |
| SCHEMBL6928553 | 0.87 | MMP13 (0.72) | MMP13MMP1MMP9ADAM17MMP2 | |
| SCHEMBL1847769 | 0.86 | MMP1 (1.00) | MMP13MMP1MMP9ADAM17MMP2 | |
| SCHEMBL7569709 | 0.86 | MMP13 (0.70) | MMP13MMP1MMP9ADAM17MMP2 | |
| SCHEMBL6927179 | 0.86 | MMP1 (1.00) | MMP13MMP1MMP9ADAM17MMP2 | |
| SCHEMBL10419954 | 0.85 | MMP1 (0.64) | MMP13MMP1MMP9ADAM17MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0970046-A1 | N-HYDROXY-2-(ALKYL, ARYL, OR HETEROARYL SULFANYL, SULFINYL OR SULFONYL)-3-SUBSTITUTED ALKYL, ARYL OR HETEROARYLAMIDES AS MATRIX METALLOPROTEINASE INHIBITORS | American Cyanamid Company (US) | 2000-01-12 | — | — | EP | disclosed |
| WO-1998038163-A1 | N-HYDROXY-2-(ALKYL, ARYL, OR HETEROARYL SULFANYL, SULFINYL OR SULFONYL)-3-SUBSTITUTED ALKYL, ARYL OR HETEROARYLAMIDES AS MATRIX METALLOPROTEINASE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 1998-09-03 | — | — | WO | disclosed |