Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 4/20 | 0.51 |
| ▸ | CHKA known ✓ | P35790 | 7/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | BCHE | P06276 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16591502 | 0.98 | ACHE (0.49) | ACHECHKALMNAALDH1A1HTT | |
| Bromide SCHEMBL7376257 | 0.83 | CYP2D6 (0.41) | ACHEBCHE | |
| SCHEMBL4402638 | 0.73 | CHRNA7 (0.39) | ACHECHKABCHE | |
| SCHEMBL3248545 | 0.71 | TSHR (0.33) | ACHEBCHE | |
| Bromide SCHEMBL3601825 | 0.71 | ACHE (0.89) | ACHEBCHE | |
| SCHEMBL4400686 | 0.69 | CHRNA7 (0.47) | ACHEBCHE | |
| Benzyl Viologen SCHEMBL4079047 | 0.69 | ALDH1A1 (0.71) | ACHECHKALMNAALDH1A1HTT | |
| SCHEMBL1127774 | 0.68 | ACHE (0.85) | ACHEBCHE | |
| Bromide SCHEMBL365151 | 0.68 | CHKA (0.61) | ACHECHKALMNAALDH1A1HTT | |
| Bromide SCHEMBL28611338 | 0.68 | CHKA (0.61) | ACHECHKALMNAALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5286733-A | Treating psychoses | STERLING WINTHROP INC. (US) | 1994-02-15 | — | — | US | disclosed |
| US-5240935-A | Central nervous system disorders | STERLING WINTHROP INC. (US) | 1993-08-31 | — | — | US | disclosed |