Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 10/20 | 0.51 |
| ▸ | MAOA | P21397 | 10/20 | 0.51 |
| ▸ | RCOR1 | Q9UKL0 | 4/20 | 0.51 |
| ▸ | KDM1B | Q8NB78 | 2/20 | 0.51 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.50 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.50 |
| ▸ | ITGAV | P06756 | 2/20 | 0.50 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.50 |
| ▸ | ITGB5 | P18084 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 8/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7347314 | 0.87 | ALDH1A1 (0.45) | ITGB3ITGB1ITGAVITGA2BITGB5 | |
| SCHEMBL7347347 | 0.86 | ITGB3 (0.48) | KDM1AMAOARCOR1KDM1BITGB3 | |
| SCHEMBL7376998 | 0.84 | ITGB3 (0.68) | KDM1AMAOARCOR1KDM1BITGB3 | |
| SCHEMBL7377969 | 0.78 | KMT2A (0.51) | ITGB3ITGB1ITGAVITGA2BITGB5 | |
| SCHEMBL7510028 | 0.75 | CA12 (0.51) | ITGB3ITGB1ITGAVITGA2BITGB5 | |
| SCHEMBL7347325 | 0.75 | NPC1 (0.41) | ITGB3ITGB1ITGAVITGA2BITGB5 | |
| Bicarbonate SCHEMBL7764859 | 0.74 | HDAC3 (0.51) | KDM1AMAOARCOR1KDM1BITGB3 | |
| SCHEMBL7769226 | 0.74 | KMT2A (0.47) | KDM1AMAOARCOR1KDM1BITGB3 | |
| SCHEMBL8687140 | 0.73 | KMT2A (0.65) | NPC1KMT2AMEN1RAB9ASMN1; SMN2 | |
| SCHEMBL7376667 | 0.73 | ITGB3 (0.52) | ITGB3ITGA2BNPC1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889875-B1 | CYCLOPROPYL ALKANOIC ACID DERIVATIVES | SEARLE & CO (US) | 2001-06-20 | — | — | EP | claimed |
| EP-0889875-A1 | CYCLOPROPYL ALKANOIC ACID DERIVATIVES | G.D. SEARLE & CO. (US) | 1999-01-13 | — | — | EP | claimed |
| WO-1997036858-A1 | CYCLOPROPYL ALKANOIC ACID DERIVATIVES | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | claimed |
| EP-0889875-B1 | CYCLOPROPYL ALKANOIC ACID DERIVATIVES | SEARLE & CO (US) | 2001-06-20 | — | — | EP | disclosed |
| EP-0889875-A1 | CYCLOPROPYL ALKANOIC ACID DERIVATIVES | G.D. SEARLE & CO. (US) | 1999-01-13 | — | — | EP | disclosed |
| WO-1997036858-A1 | CYCLOPROPYL ALKANOIC ACID DERIVATIVES | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | disclosed |