Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 2/20 | 0.48 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.48 |
| ▸ | ITGAV | P06756 | 2/20 | 0.48 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.48 |
| ▸ | ITGB5 | P18084 | 2/20 | 0.48 |
| ▸ | KDM1A | O60341 | 11/20 | 0.47 |
| ▸ | MAOA | P21397 | 10/20 | 0.47 |
| ▸ | RCOR1 | Q9UKL0 | 4/20 | 0.47 |
| ▸ | KDM1B | Q8NB78 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 9/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7347325 | 0.87 | NPC1 (0.41) | ITGB3ITGB1ITGAVITGA2BITGB5 | |
| SCHEMBL7347339 | 0.86 | KDM1A (0.51) | ITGB3ITGB1ITGAVITGA2BITGB5 | |
| SCHEMBL7377004 | 0.85 | ITGB3 (0.64) | ITGB3ITGB1ITGAVITGA2BITGB5 | |
| SCHEMBL7377976 | 0.79 | KMT2A (0.48) | ITGB3ITGB1ITGAVITGA2BITGB5 | |
| SCHEMBL7510036 | 0.77 | CA12 (0.49) | ITGB3ITGB1ITGAVITGA2BITGB5 | |
| SCHEMBL7452094 | 0.76 | ITGB3 (0.48) | ITGB3ITGA2BKMT2AMEN1NPC1 | |
| SCHEMBL7769230 | 0.75 | KMT2A (0.46) | ITGB3ITGA2BKDM1AMAOARCOR1 | |
| SCHEMBL7378476 | 0.74 | ITGB3 (0.54) | ITGB3ITGB1ITGAVITGA2BITGB5 | |
| SCHEMBL7380254 | 0.74 | ITGB3 (0.49) | ITGB3ITGB1ITGAVITGA2BITGB5 | |
| SCHEMBL7353486 | 0.74 | ITGB3 (0.46) | ITGB3ITGB1ITGAVITGA2BITGB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889875-B1 | CYCLOPROPYL ALKANOIC ACID DERIVATIVES | SEARLE & CO (US) | 2001-06-20 | — | — | EP | claimed |
| EP-0889875-A1 | CYCLOPROPYL ALKANOIC ACID DERIVATIVES | G.D. SEARLE & CO. (US) | 1999-01-13 | — | — | EP | claimed |
| WO-1997036858-A1 | CYCLOPROPYL ALKANOIC ACID DERIVATIVES | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | claimed |
| EP-0889875-B1 | CYCLOPROPYL ALKANOIC ACID DERIVATIVES | SEARLE & CO (US) | 2001-06-20 | — | — | EP | disclosed |