Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 5/20 | 0.46 |
| ▸ | ITGAV | P06756 | 5/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.46 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.46 |
| ▸ | ITGB5 | P18084 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.43 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7347325 | 0.89 | NPC1 (0.41) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7353478 | 0.87 | ALDH1A1 (0.49) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7377004 | 0.83 | ITGB3 (0.64) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7765706 | 0.80 | ITGB3 (0.43) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7373351 | 0.79 | ITGB3 (0.68) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7347314 | 0.75 | ALDH1A1 (0.45) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7349100 | 0.75 | ITGB3 (0.48) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7347347 | 0.74 | ITGB3 (0.48) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7409787 | 0.72 | CYP3A4 (0.42) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7458432 | 0.72 | ITGB3 (0.72) | ITGB3ITGAVITGA2BITGB1ITGB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889875-B1 | CYCLOPROPYL ALKANOIC ACID DERIVATIVES | SEARLE & CO (US) | 2001-06-20 | — | — | EP | claimed |
| EP-0889875-A1 | CYCLOPROPYL ALKANOIC ACID DERIVATIVES | G.D. SEARLE & CO. (US) | 1999-01-13 | — | — | EP | claimed |
| WO-1997036858-A1 | CYCLOPROPYL ALKANOIC ACID DERIVATIVES | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | claimed |
| EP-0889875-B1 | CYCLOPROPYL ALKANOIC ACID DERIVATIVES | SEARLE & CO (US) | 2001-06-20 | — | — | EP | disclosed |