Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | ACE | P12821 | 7/20 | 0.40 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | PSMB1 | P20618 | 3/20 | 0.38 |
| ▸ | PSMB2 | P49721 | 3/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | PSMB11 | A5LHX3 | 2/20 | 0.38 |
| ▸ | PSMA7 | O14818 | 2/20 | 0.38 |
| ▸ | PSMA1 | P25786 | 2/20 | 0.38 |
| ▸ | PSMA2 | P25787 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6701578 | 1.00 | REN (0.44) | RENGAAPOLBACECAPN1 | |
| SCHEMBL7347210 | 0.93 | GAA (0.46) | RENGAAPOLBACECAPN1 | |
| SCHEMBL7348947 | 0.89 | CAPN1 (0.46) | RENGAAPOLBACECAPN1 | |
| SCHEMBL7380813 | 0.85 | REN (0.45) | RENGAAPOLBACECAPN1 | |
| SCHEMBL7356334 | 0.84 | POLB (0.43) | RENGAAPOLBACECAPN1 | |
| SCHEMBL7348519 | 0.84 | POLB (0.43) | RENGAAPOLBACECAPN1 | |
| SCHEMBL7356125 | 0.81 | GAA (0.49) | RENGAAPOLBACECAPN1 | |
| Hydrochloric Acid SCHEMBL4447405 | 0.81 | KMT2A (0.43) | GAAPOLBKDM4ECYP2C19PSMB1 | |
| SCHEMBL6701580 | 0.80 | OPRM1 (0.48) | ACECAPN1OPRM1OPRD1OPRK1 | |
| SCHEMBL7347378 | 0.80 | OPRM1 (0.48) | ACECAPN1OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0644892-A1 | INHIBITORS OF ANGIOTENSIN I CHYMASE(S) INCLUDING HUMAN HEART CHYMASE | PFIZER INC. (US) | 1995-03-29 | — | — | EP | claimed |
| WO-1993025574-A1 | INHIBITORS OF ANGIOTENSIN I CHYMASE(S) INCLUDING HUMAN HEART CHYMASE | PFIZER INC. (US) | 1993-12-23 | — | — | WO | claimed |
| EP-0644892-A1 | INHIBITORS OF ANGIOTENSIN I CHYMASE(S) INCLUDING HUMAN HEART CHYMASE | PFIZER INC. (US) | 1995-03-29 | — | — | EP | disclosed |
| WO-1993025574-A1 | INHIBITORS OF ANGIOTENSIN I CHYMASE(S) INCLUDING HUMAN HEART CHYMASE | PFIZER INC. (US) | 1993-12-23 | — | — | WO | disclosed |