Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | ACE | P12821 | 5/20 | 0.47 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.47 |
| ▸ | XIAP | P98170 | 5/20 | 0.47 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.46 |
| ▸ | TACR1 | P25103 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6701580 | 1.00 | OPRM1 (0.48) | OPRM1OPRD1OPRK1ACEACE2 | |
| SCHEMBL7347204 | 0.93 | OPRM1 (0.49) | OPRM1OPRD1OPRK1ACEACE2 | |
| SCHEMBL7348938 | 0.88 | CAPN1 (0.57) | OPRM1OPRD1OPRK1XIAPCAPN1 | |
| SCHEMBL7348952 | 0.88 | CAPN1 (0.57) | OPRM1OPRD1OPRK1XIAPCAPN1 | |
| SCHEMBL7380816 | 0.86 | REN (0.48) | OPRM1ACEACE2TACR1 | |
| SCHEMBL7355087 | 0.83 | ACE (0.60) | ACEACE2 | |
| SCHEMBL7356337 | 0.83 | ELANE (0.57) | XIAP | |
| SCHEMBL7348523 | 0.83 | ELANE (0.57) | XIAP | |
| SCHEMBL7348515 | 0.83 | ELANE (0.57) | XIAP | |
| SCHEMBL7356132 | 0.82 | F2 (0.51) | OPRM1OPRD1OPRK1ACEACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0644892-A1 | INHIBITORS OF ANGIOTENSIN I CHYMASE(S) INCLUDING HUMAN HEART CHYMASE | PFIZER INC. (US) | 1995-03-29 | — | — | EP | claimed |
| WO-1993025574-A1 | INHIBITORS OF ANGIOTENSIN I CHYMASE(S) INCLUDING HUMAN HEART CHYMASE | PFIZER INC. (US) | 1993-12-23 | — | — | WO | claimed |
| EP-0644892-A1 | INHIBITORS OF ANGIOTENSIN I CHYMASE(S) INCLUDING HUMAN HEART CHYMASE | PFIZER INC. (US) | 1995-03-29 | — | — | EP | disclosed |
| WO-1993025574-A1 | INHIBITORS OF ANGIOTENSIN I CHYMASE(S) INCLUDING HUMAN HEART CHYMASE | PFIZER INC. (US) | 1993-12-23 | — | — | WO | disclosed |