Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | FDPS | P14324 | 3/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.33 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.32 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.32 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11824865 | 0.81 | HSPD1 (0.43) | CA2ACE2HSPD1BLMHSPE1 | |
| SCHEMBL9955057 | 0.78 | EPHX1 (0.32) | EPHX1 | |
| SCHEMBL301700 | 0.77 | CA1 (0.38) | EPHX1FDPSCA1CA2ACE2 | |
| SCHEMBL7379715 | 0.75 | CA1 (0.41) | EPHX1FDPSCA1CA2ACE2 | |
| SCHEMBL9954809 | 0.73 | HSPD1 (0.49) | FDPSGGPS1HSPD1BLMHSPE1 | |
| SCHEMBL28928385 | 0.73 | HSPD1 (0.49) | FDPSGGPS1HSPD1BLMHSPE1 | |
| SCHEMBL28984579 | 0.73 | GPR84 (0.40) | CA1CA2ACE2HSPD1BLM | |
| SCHEMBL10535324 | 0.73 | FDPS (0.41) | EPHX1FDPSCA1CA2SCN5A | |
| SCHEMBL9282122 | 0.73 | FDPS (0.41) | FDPSCA1CA2SCN5ASCN9A | |
| SCHEMBL28467287 | 0.72 | EPHX1 (0.39) | EPHX1FDPSGGPS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992003429-A1 | RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1992-03-05 | — | — | WO | claimed |
| EP-0543936-A4 | RENIN INHIBITORS | — | 1993-06-30 | — | — | EP | disclosed |
| EP-0543936-A1 | RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1993-06-02 | — | — | EP | disclosed |