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Dimethylamine

Dimethylamine

SCHEMBL7347396

CCC(C)C(C(=O)N[C@@H](Cc1ccc2ccccc2c1)[C@@H](O)[C@@H](O)CC(C)C)N(C(=O)C(C)NC1CCCCC1)C(=O)N(C)CC.CNC

nearest known ligand 0.55

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ REN P00797 14/20 0.55
▸ PSEN1 P49768 1/20 0.37
▸ PSEN2 P49810 1/20 0.37
▸ APH1B Q8WW43 1/20 0.37
▸ NCSTN Q92542 1/20 0.37
▸ APH1A Q96BI3 1/20 0.37
▸ PSENEN Q9NZ42 1/20 0.37
▸ BDKRB2 P30411 1/20 0.37
▸ MME P08473 1/20 0.35
▸ ACE P12821 1/20 0.35
▸ CPA1 P15085 1/20 0.35
▸ ACE2 Q9BYF1 1/20 0.35
▸ CCR1 P32246 1/20 0.35
▸ CTSD P07339 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7347697 0.91 REN (0.54) RENPSEN1PSEN2APH1BNCSTN
SCHEMBL9439736 0.87 REN (0.57) REN
Hydrochloric Acid SCHEMBL7354081 0.86 REN (0.57) RENBDKRB2
SCHEMBL7347692 0.79 REN (0.57) RENPSEN1PSEN2APH1BNCSTN
SCHEMBL7346476 0.78 REN (0.40) REN
SCHEMBL9439731 0.76 REN (0.58) REN
Hydrochloric Acid SCHEMBL7354075 0.75 REN (0.58) REN
SCHEMBL7347699 0.74 REN (0.66) RENPSEN1PSEN2APH1BNCSTN
SCHEMBL7347400 0.73 REN (0.74) RENPSEN1PSEN2APH1BNCSTN
SCHEMBL7347634 0.73 REN (0.69) RENCTSD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5338726-A Hypotensive agents, antiulcer agents ABBOTT LABORATORIES (US) 1994-08-16 — — US claimed
EP-0569487-A4 — — 1994-04-27 — — EP claimed
EP-0569487-A1 ENDOTHELIN CONVERTING ENZYME INHIBITORS ABBOTT LABORATORIES (US) 1993-11-18 — — EP claimed
WO-1992013545-A1 ENDOTHELIN CONVERTING ENZYME INHIBITORS ABBOTT LABORATORIES (US) 1992-08-20 — — WO claimed
US-5338726-A Hypotensive agents, antiulcer agents ABBOTT LABORATORIES (US) 1994-08-16 — — US disclosed
EP-0569487-A4 — — 1994-04-27 — — EP disclosed
EP-0569487-A1 ENDOTHELIN CONVERTING ENZYME INHIBITORS ABBOTT LABORATORIES (US) 1993-11-18 — — EP disclosed
WO-1992013545-A1 ENDOTHELIN CONVERTING ENZYME INHIBITORS ABBOTT LABORATORIES (US) 1992-08-20 — — WO disclosed