Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 15/20 | 0.57 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.41 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
| ▸ | CTSE | P14091 | 1/20 | 0.39 |
| ▸ | PGC | P20142 | 1/20 | 0.39 |
| ▸ | MME | P08473 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
| ▸ | CPA1 | P15085 | 1/20 | 0.38 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9439731 | 0.89 | REN (0.58) | REN | |
| Hydrochloric Acid SCHEMBL7354075 | 0.88 | REN (0.58) | REN | |
| SCHEMBL7346474 | 0.86 | REN (0.42) | RENCTSDCTSEPGC | |
| SCHEMBL7347634 | 0.86 | REN (0.69) | RENCTSDCTSEPGC | |
| SCHEMBL7347699 | 0.83 | REN (0.66) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7347697 | 0.83 | REN (0.54) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9439739 | 0.79 | REN (0.67) | RENCTSD | |
| SCHEMBL7347388 | 0.79 | REN (0.64) | RENPSEN1PSEN2APH1BNCSTN | |
| Dimethylamine SCHEMBL7347396 | 0.79 | REN (0.55) | RENPSEN1PSEN2APH1BNCSTN | |
| Hydrochloric Acid SCHEMBL7354086 | 0.79 | REN (0.67) | RENCTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5338726-A | Hypotensive agents, antiulcer agents | ABBOTT LABORATORIES (US) | 1994-08-16 | — | — | US | claimed |
| EP-0569487-A4 | — | — | 1994-04-27 | — | — | EP | claimed |
| EP-0569487-A1 | ENDOTHELIN CONVERTING ENZYME INHIBITORS | ABBOTT LABORATORIES (US) | 1993-11-18 | — | — | EP | claimed |
| WO-1992013545-A1 | ENDOTHELIN CONVERTING ENZYME INHIBITORS | ABBOTT LABORATORIES (US) | 1992-08-20 | — | — | WO | claimed |
| US-5338726-A | Hypotensive agents, antiulcer agents | ABBOTT LABORATORIES (US) | 1994-08-16 | — | — | US | disclosed |
| EP-0569487-A4 | — | — | 1994-04-27 | — | — | EP | disclosed |
| EP-0569487-A1 | ENDOTHELIN CONVERTING ENZYME INHIBITORS | ABBOTT LABORATORIES (US) | 1993-11-18 | — | — | EP | disclosed |
| WO-1992013545-A1 | ENDOTHELIN CONVERTING ENZYME INHIBITORS | ABBOTT LABORATORIES (US) | 1992-08-20 | — | — | WO | disclosed |