Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 16/20 | 0.54 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
| ▸ | CTSD | P07339 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethylamine SCHEMBL7347396 | 0.91 | REN (0.55) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9439736 | 0.90 | REN (0.57) | REN | |
| Hydrochloric Acid SCHEMBL7354081 | 0.90 | REN (0.57) | REN | |
| SCHEMBL7346476 | 0.87 | REN (0.40) | REN | |
| SCHEMBL7347692 | 0.83 | REN (0.57) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9439731 | 0.78 | REN (0.58) | REN | |
| SCHEMBL7347699 | 0.78 | REN (0.66) | RENPSEN1PSEN2APH1BNCSTN | |
| Hydrochloric Acid SCHEMBL7354075 | 0.78 | REN (0.58) | REN | |
| SCHEMBL7347634 | 0.76 | REN (0.69) | RENCTSD | |
| SCHEMBL9294998 | 0.74 | REN (0.54) | RENCTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5338726-A | Hypotensive agents, antiulcer agents | ABBOTT LABORATORIES (US) | 1994-08-16 | — | — | US | claimed |
| WO-1992013545-A1 | ENDOTHELIN CONVERTING ENZYME INHIBITORS | ABBOTT LABORATORIES (US) | 1992-08-20 | — | — | WO | claimed |
| US-5338726-A | Hypotensive agents, antiulcer agents | ABBOTT LABORATORIES (US) | 1994-08-16 | — | — | US | disclosed |
| WO-1992013545-A1 | ENDOTHELIN CONVERTING ENZYME INHIBITORS | ABBOTT LABORATORIES (US) | 1992-08-20 | — | — | WO | disclosed |