Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 6/20 | 0.52 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | CASP1 | P29466 | 3/20 | 0.51 |
| ▸ | CASP7 | P55210 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.48 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.48 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.48 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10367116 | 0.84 | CACNA1B (0.50) | GAACACNA1BADORA3ALDH1A1KDM4E | |
| SCHEMBL7350838 | 0.83 | HSD17B10 (0.63) | GAACACNA1BADORA3ALDH1A1KDM4E | |
| SCHEMBL7343709 | 0.83 | CACNA1B (0.52) | CACNA1BADORA3TSHRCACNA1FCACNA1D | |
| SCHEMBL7349297 | 0.83 | CACNA1B (0.57) | CACNA1BADORA3CACNA1FCACNA1DCACNA1S | |
| SCHEMBL7341777 | 0.83 | CACNA1F (0.63) | ADORA3TSHRCACNA1FCACNA1DCACNA1S | |
| SCHEMBL7345495 | 0.83 | POLB (0.58) | CACNA1BADORA3TSHRNPSR1CACNA1F | |
| SCHEMBL7162019 | 0.83 | GAA (0.63) | GAACACNA1BADORA3ALDH1A1KDM4E | |
| SCHEMBL7344603 | 0.83 | KDM4E (0.67) | GAAADORA3ALDH1A1KDM4EHPGD | |
| SCHEMBL7344610 | 0.82 | HSD17B10 (0.52) | CACNA1BADORA3ALDH1A1KDM4EHPGD | |
| SCHEMBL7343603 | 0.82 | MAPT (0.70) | ADORA3KDM4ETSHRNPSR1CACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4833150-A | HYPOTENSIVES, ANTIARRHYTHMIA AGENTS | NELSON RESEARCH & DEVELOPMENT CO. (US) | 1989-05-23 | — | — | US | disclosed |
| US-4652573-A | HYPOTENSIVE AGENTS | NELSON RESEARCH & DEVELOPMENT CO. (US) | 1987-03-24 | — | — | US | disclosed |
| EP-0194685-A1 | 1,4-Dihydropyridines | Whitby Research Incorporated (US) | 1986-09-17 | — | — | EP | disclosed |