Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.48 |
| ▸ | CASP1 | P29466 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.47 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.47 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.47 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | CASP7 | P55210 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10744164 | 0.83 | ALDH1A1 (0.54) | HSD17B10TSHRADORA3KDM4EHPGD | |
| SCHEMBL7349611 | 0.83 | HSD17B10 (0.64) | HSD17B10TSHRCACNA1BADORA3KDM4E | |
| SCHEMBL7341777 | 0.82 | CACNA1F (0.63) | TSHRADORA3CACNA1FCACNA1DCACNA1S | |
| SCHEMBL7345495 | 0.82 | POLB (0.58) | TSHRCACNA1BADORA3CACNA1FCACNA1D | |
| SCHEMBL7343709 | 0.82 | CACNA1B (0.52) | TSHRCACNA1BADORA3CACNA1FCACNA1D | |
| SCHEMBL7347758 | 0.82 | GAA (0.52) | HSD17B10TSHRCACNA1BADORA3KDM4E | |
| SCHEMBL7349297 | 0.82 | CACNA1B (0.57) | CACNA1BADORA3CACNA1FCACNA1DCACNA1S | |
| SCHEMBL7344613 | 0.81 | ADORA3 (0.61) | HSD17B10TSHRCACNA1BADORA3KDM4E | |
| SCHEMBL7343547 | 0.80 | ADORA3 (0.47) | HSD17B10TSHRCACNA1BADORA3KDM4E | |
| SCHEMBL7342397 | 0.80 | ADORA3 (0.47) | HSD17B10TSHRADORA3KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4833150-A | HYPOTENSIVES, ANTIARRHYTHMIA AGENTS | NELSON RESEARCH & DEVELOPMENT CO. (US) | 1989-05-23 | — | — | US | disclosed |
| US-4652573-A | HYPOTENSIVE AGENTS | NELSON RESEARCH & DEVELOPMENT CO. (US) | 1987-03-24 | — | — | US | disclosed |
| EP-0194685-A1 | 1,4-Dihydropyridines | Whitby Research Incorporated (US) | 1986-09-17 | — | — | EP | disclosed |