Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 10/20 | 0.45 |
| ▸ | MMP1 | P03956 | 9/20 | 0.45 |
| ▸ | MMP7 | P09237 | 9/20 | 0.45 |
| ▸ | MMP9 | P14780 | 9/20 | 0.45 |
| ▸ | MMP13 | P45452 | 7/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7056006 | 0.85 | MMP1 (0.51) | MMP3MMP1MMP7MMP9MMP13 | |
| SCHEMBL7056754 | 0.85 | MMP1 (0.44) | MMP3MMP1MMP7MMP9MMP13 | |
| SCHEMBL7058714 | 0.81 | MMP1 (0.46) | MMP3MMP1MMP7MMP9MMP13 | |
| SCHEMBL7053645 | 0.80 | MMP1 (0.45) | MMP3MMP1MMP7MMP9MMP13 | |
| SCHEMBL7348210 | 0.77 | MMP1 (0.36) | MMP3MMP1MMP7MMP9ALDH1A1 | |
| SCHEMBL7053212 | 0.73 | MMP1 (0.50) | MMP3MMP1MMP7MMP9MMP13 | |
| SCHEMBL7351275 | 0.71 | KCNQ1 (0.34) | MMP3MMP1MMP7MMP9MMP13 | |
| SCHEMBL7051967 | 0.71 | MMP1 (0.52) | MMP3MMP1MMP7MMP9MMP13 | |
| SCHEMBL7058112 | 0.71 | ALDH1A1 (0.39) | MMP3MMP1MMP7MMP9MMP13 | |
| SCHEMBL7122121 | 0.71 | MMP13 (0.52) | MMP3MMP1MMP7MMP9MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5958929-A | CONGESTIVE HEART FAILURE; HYPOTENSIVE AGENTS | SANOFI (FR) | 1999-09-28 | — | — | US | claimed |
| EP-0948489-A1 | PIPERAZINE COMPOUNDS AS INHIBITORS OF MMP OR TNF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-10-13 | — | — | EP | disclosed |
| US-5958929-A | CONGESTIVE HEART FAILURE; HYPOTENSIVE AGENTS | SANOFI (FR) | 1999-09-28 | — | — | US | disclosed |
| WO-1998027069-A1 | PIPERAZINE COMPOUNDS AS INHIBITORS OF MMP OR TNF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-06-25 | — | — | WO | disclosed |
| US-5736548-A | CYCLIC GUANOSINE 3*,5*-MONOPHOSPHATE PHOSPHODIESTERASE INHIBITORS; TREATING HEART FAILURE, HYPERTENSION | SANOFI (FR) | 1998-04-07 | — | — | US | disclosed |