Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | UBE2M | P61081 | 1/20 | 0.39 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7351451 | 0.84 | SLC6A2 (0.39) | KCNH2MEN1KMT2AALDH1A1HTR4 | |
| SCHEMBL9274208 | 0.79 | HTR4 (0.34) | HTR4 | |
| SCHEMBL7346867 | 0.75 | SLC6A2 (0.46) | KCNH2RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL7346874 | 0.74 | KCNH2 (0.46) | KCNH2ALDH1A1HTR4 | |
| SCHEMBL7333296 | 0.73 | KCNH2 (0.45) | KCNH2RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL9340442 | 0.71 | KDM4E (0.45) | KCNH2RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL7348366 | 0.70 | KCNH2 (0.46) | KCNH2RAB9AMEN1KMT2AHTR4 | |
| SCHEMBL7346871 | 0.70 | KCNH2 (0.46) | KCNH2RAB9A | |
| SCHEMBL27416355 | 0.70 | KCNH2 (0.45) | KCNH2RAB9AKDM4EALDH1A1PMP22 | |
| SCHEMBL7357788 | 0.69 | HTR7 (0.55) | KCNH2RAB9AHTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994008965-A1 | N-ALKYLPIPERIDINYL-4-METHYL CARBOXYLIC ESTERS/AMIDES OF CONDENSED RING SYSTEMS AS 5-HT4 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-04-28 | — | — | WO | claimed |
| US-5726187-A | N-alkylpiperidinyl-4-methyl carboxylic esters/amides of condensed ring systems as 5-HT4 receptor antagonists | SMITHKLINE BEECHAM PLC (GB) | 1998-03-10 | — | — | US | disclosed |
| WO-1994008965-A1 | N-ALKYLPIPERIDINYL-4-METHYL CARBOXYLIC ESTERS/AMIDES OF CONDENSED RING SYSTEMS AS 5-HT4 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-04-28 | — | — | WO | disclosed |