Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 7/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 2/20 | 0.52 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | MME | P08473 | 2/20 | 0.38 |
| ▸ | ACE | P12821 | 2/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7312998 | 0.92 | ALDH1A1 (0.45) | POLBALDH1A1MAPTL3MBTL1HPGD | |
| SCHEMBL7350634 | 0.86 | ALDH1A1 (0.58) | POLBALDH1A1MAPTL3MBTL1HPGD | |
| SCHEMBL7313009 | 0.85 | ALDH1A1 (0.46) | POLBALDH1A1MAPTL3MBTL1HPGD | |
| SCHEMBL7348231 | 0.84 | ALDH1A1 (0.45) | POLBALDH1A1MAPTL3MBTL1HPGD | |
| SCHEMBL7341599 | 0.82 | ALDH1A1 (0.56) | POLBALDH1A1MAPTL3MBTL1HPGD | |
| SCHEMBL7343460 | 0.82 | ALDH1A1 (0.53) | POLBALDH1A1MAPTL3MBTL1HPGD | |
| SCHEMBL9182534 | 0.81 | CTSS (0.55) | CYP3A4ACE | |
| SCHEMBL7337822 | 0.81 | CTSS (0.55) | CYP3A4ACE | |
| SCHEMBL7349092 | 0.80 | KMT2A (0.49) | POLBALDH1A1MAPTL3MBTL1HPGD | |
| SCHEMBL7350803 | 0.80 | POLB (0.49) | POLBALDH1A1MAPTL3MBTL1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0603873-B1 | Aminoketone derivatives | MITSUBISHI CHEM CORP (JP) | 1998-04-15 | — | — | EP | disclosed |
| US-5424325-A | Inibitors of thiol protease and may be used as therapeutic agents for treating muscular dystrophy, cataracts, strokes | MITSUBISHI KASEI CORPORATION (JP) | 1995-06-13 | — | — | US | disclosed |
| EP-0603873-A1 | Aminoketone derivatives | Mitsubishi Chemical Corporation (JP) | 1994-06-29 | — | — | EP | disclosed |