Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | PYGL | P06737 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | ACLY | P53396 | 1/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28779396 | 0.84 | TDP1 (0.43) | PYGLKDM4ENPC1RAB9AMAPT | |
| SCHEMBL5783457 | 0.83 | ALDH1A1 (0.53) | SMN1; SMN2TSHRCASP1PYGLKDM4E | |
| Hydrochloric Acid SCHEMBL28779394 | 0.83 | TDP1 (0.42) | PYGLKDM4ENPC1RAB9AMAPT | |
| Bicarbonate SCHEMBL7359619 | 0.83 | EPHX1 (0.61) | KDM4ENPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL19526332 | 0.81 | KMT2A (0.59) | SMN1; SMN2TSHRPYGLKDM4ERAB9A | |
| SCHEMBL2745967 | 0.80 | CYP1A2 (0.49) | CASP1NPC1RAB9APOLBTDP1 | |
| SCHEMBL7978757 | 0.80 | KLK1 (0.48) | SMN1; SMN2PYGLNPC1RAB9APLAU | |
| SCHEMBL17188149 | 0.80 | EPHX1 (0.53) | SMN1; SMN2TSHRCASP1PYGLKDM4E | |
| SCHEMBL1304698 | 0.79 | RORC (0.54) | SMN1; SMN2TSHRCASP1KDM4ENPC1 | |
| SCHEMBL5777560 | 0.79 | MAPT (0.73) | SMN1; SMN2TSHRCASP1PYGLKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0048433-B1 | NOVEL AMIDINE COMPOUNDS, PROCESS FOR PRODUCING SAME AND ANTI-COMPLEMENT AGENT COMPRISING THEM | TORII & CO., LTD. (JP) | 1986-05-28 | — | — | EP | disclosed |
| US-4532255-A | Amidine compounds and anticomplement agent comprising same | TORII & CO., LTD. (JP) | 1985-07-30 | — | — | US | disclosed |
| US-4454338-A | 6-AMIDINO-2-NATHTHYL-4-GUANIDINOBENZOATE | TORII & CO., LTD. (JP) | 1984-06-12 | — | — | US | disclosed |
| EP-0048433-A2 | Novel amidine compounds, process for producing same and anti-complement agent comprising them | TORII & CO., LTD. (JP) | 1982-03-31 | — | — | EP | disclosed |