Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 4/20 | 0.54 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.54 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.46 |
| ▸ | MET | P08581 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.44 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.44 |
| ▸ | LDHA | P00338 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1587133 | 0.84 | AKR1C3 (0.73) | AKR1C3AKR1C2AKR1C1PTGS1L3MBTL1 | |
| SCHEMBL22095156 | 0.84 | AKR1C3 (0.73) | AKR1C3AKR1C2AKR1C1PTGS1L3MBTL1 | |
| SCHEMBL28140713 | 0.82 | AKR1C3 (0.54) | AKR1C3AKR1C2AKR1C1PTGS1ALDH1A1 | |
| SCHEMBL27146207 | 0.82 | AKR1C3 (0.54) | AKR1C3AKR1C2AKR1C1PTGS1L3MBTL1 | |
| SCHEMBL7998270 | 0.81 | LMNA (0.57) | AKR1C3AKR1C2AKR1C1PTGS1ALDH1A1 | |
| SCHEMBL28580616 | 0.81 | AKR1C3 (0.53) | AKR1C3AKR1C2AKR1C1PTGS1L3MBTL1 | |
| SCHEMBL10634318 | 0.80 | AKR1C3 (0.52) | AKR1C3AKR1C2AKR1C1PTGS1L3MBTL1 | |
| SCHEMBL6944962 | 0.80 | L3MBTL1 (0.48) | AKR1C3AKR1C2AKR1C1PTGS1L3MBTL1 | |
| SCHEMBL15326052 | 0.79 | ALDH1A1 (0.50) | AKR1C3AKR1C2L3MBTL1ALDH1A1KCNQ2 | |
| SCHEMBL28579206 | 0.78 | MAPT (0.51) | AKR1C3AKR1C2AKR1C1PTGS1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663416-A | ENZYME INHIBITORS AS ANTIINFLAMMATORY AGENTS OR DERMATITIS TREATMENT | CORTECH INC. | 1997-09-02 | — | — | US | disclosed |
| EP-0446047-B1 | Benzisothiazolinone-1-dioxide derivatives as elastase inhibitors | UNILEVER PLC (GB) | 1997-06-11 | — | — | EP | disclosed |
| US-5411978-A | Aging resistance, human skin | CHESEBROUGH-POND'S USA CO., DIVISION OF CONOPCO, INC. (US) | 1995-05-02 | — | — | US | disclosed |
| US-5338747-A | Benzoisothiazolinone-1-dioxide derivatives as elastase inhibitors | CHESEBROUGH-POND'S USA CO., DIVISION OF CONOPCO, INC. (US) | 1994-08-16 | — | — | US | disclosed |
| US-5214191-A | OXIDANT SENSITIVE AND INSENSITIVE AROMATIC ESTERS AS INHIBITORS OF HUMAN NEUTROPHIL ELASTASE | CORTECH, INC. (US) | 1993-05-25 | — | — | US | disclosed |
| EP-0465802-A1 | Oxidant sensitive and insensitive aromatic esters as inhibitors of human neutrophil elastase | CORTECH, INC. (US) | 1992-01-15 | — | — | EP | disclosed |
| CN-1056680-A | The preparation method who can be used as the 2-phenylalkanoic acid esters of human leukocytes elastase inhibitor | CORTECH INC (US) | 1991-12-04 | — | — | CN | disclosed |
| EP-0446047-A1 | Benzisothiazolinone-1-dioxide derivatives as elastase inhibitors | UNILEVER PLC (GB) | 1991-09-11 | — | — | EP | disclosed |