Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 7/20 | 0.39 |
| ▸ | MMP1 | P03956 | 6/20 | 0.39 |
| ▸ | MMP9 | P14780 | 6/20 | 0.39 |
| ▸ | MMP13 | P45452 | 4/20 | 0.39 |
| ▸ | MMP7 | P09237 | 3/20 | 0.39 |
| ▸ | MMP8 | P22894 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 2/20 | 0.36 |
| ▸ | MMP14 | P50281 | 2/20 | 0.36 |
| ▸ | MMP25 | Q9NPA2 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7054228 | 0.90 | MMP1 (0.43) | MMP3MMP1MMP9MMP13MMP7 | |
| SCHEMBL7059354 | 0.89 | MMP3 (0.42) | MMP3MMP1MMP9MMP13MMP7 | |
| SCHEMBL7053484 | 0.80 | MMP13 (0.46) | MMP3MMP1MMP9MMP13MMP7 | |
| SCHEMBL7683486 | 0.79 | MMP13 (0.52) | MMP3MMP1MMP9MMP13MMP7 | |
| SCHEMBL7053853 | 0.79 | MMP13 (0.52) | MMP3MMP1MMP9MMP13MMP7 | |
| SCHEMBL7059693 | 0.78 | MMP13 (0.51) | MMP3MMP1MMP9MMP13MMP7 | |
| SCHEMBL7053487 | 0.77 | MMP1 (0.41) | MMP3MMP1MMP9MMP13MMP7 | |
| SCHEMBL7056106 | 0.77 | MMP3 (0.53) | MMP3MMP1MMP9MMP13MMP7 | |
| SCHEMBL7057123 | 0.77 | MMP13 (0.46) | MMP3MMP1MMP9MMP13MMP7 | |
| SCHEMBL7355593 | 0.77 | MMP13 (0.46) | MMP3MMP1MMP9MMP13MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948489-A1 | PIPERAZINE COMPOUNDS AS INHIBITORS OF MMP OR TNF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998027069-A1 | PIPERAZINE COMPOUNDS AS INHIBITORS OF MMP OR TNF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-06-25 | — | — | WO | disclosed |