Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CLEC4M | Q9H2X3 | 1/20 | 0.42 |
| ▸ | CDC25B | P30305 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5503774 | 0.84 | KDM4E (0.52) | KDM4ETSHRALDH1A1HSD17B10CYP1A2 | |
| SCHEMBL30424394 | 0.84 | KDM4E (0.48) | KDM4ETSHRALDH1A1HSD17B10KMT2A | |
| SCHEMBL1135530 | 0.84 | KDM4E (0.48) | KDM4ETSHRALDH1A1HSD17B10KMT2A | |
| SCHEMBL5971733 | 0.80 | HPGDS (0.55) | KDM4ETSHRALDH1A1HSD17B10KMT2A | |
| SCHEMBL5583821 | 0.79 | PBRM1 (0.38) | KDM4ETSHRALDH1A1HSD17B10CYP1A2 | |
| SCHEMBL6009595 | 0.77 | TSHR (0.61) | KDM4ETSHRALDH1A1HSD17B10CYP1A2 | |
| SCHEMBL7348395 | 0.77 | KDM4E (0.48) | KDM4ETSHRALDH1A1HSD17B10CYP1A2 | |
| SCHEMBL25222245 | 0.77 | NUDT1 (0.54) | KDM4ETSHRALDH1A1KMT2AMEN1 | |
| SCHEMBL30989297 | 0.77 | NUDT1 (0.54) | KDM4ETSHRALDH1A1KMT2AMEN1 | |
| SCHEMBL7348330 | 0.76 | KDM4E (0.47) | KDM4ETSHRALDH1A1HSD17B10CDC25B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6214834-B1 | ANGIOGENESIS INHIBITORS; ANTIINFLAMMATORY AGENTS; ANTICANCER AGENTS | DUPONT PHARMACEUTICALS COMPANY | 2001-04-10 | — | — | US | disclosed |
| WO-1998043962-A1 | HETEROCYCLIC INTEGRIN INHIBITOR PRODRUGS | DU PONT PHARMACEUTICALS COMPANY (US) | 1998-10-08 | — | — | WO | disclosed |
| US-5760028-A | TREATING CANCER METASTASIS, DIABETIC RETINOPATHY, NEOVASCULAR GLAUCOMA, THROMBOSIS, RESTENOSIS, OSTEOPOROSIS, MACULAR DEGENERATION | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-06-02 | — | — | US | disclosed |