Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CLEC4M | Q9H2X3 | 1/20 | 0.43 |
| ▸ | CDC25B | P30305 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7349359 | 0.84 | KDM4E (0.51) | KDM4ETSHRALDH1A1HSD17B10CYP1A2 | |
| SCHEMBL5971733 | 0.81 | HPGDS (0.55) | KDM4ETSHRALDH1A1HSD17B10KMT2A | |
| SCHEMBL6009595 | 0.79 | TSHR (0.61) | KDM4ETSHRALDH1A1HSD17B10CYP1A2 | |
| SCHEMBL7348395 | 0.78 | KDM4E (0.48) | KDM4ETSHRALDH1A1HSD17B10CYP1A2 | |
| SCHEMBL7348330 | 0.77 | KDM4E (0.47) | KDM4ETSHRALDH1A1HSD17B10CDC25B | |
| SCHEMBL6008342 | 0.74 | TSHR (0.54) | KDM4ETSHRALDH1A1HSD17B10CYP1A2 | |
| SCHEMBL15836985 | 0.74 | TSHR (0.54) | KDM4ETSHRALDH1A1HSD17B10CYP1A2 | |
| SCHEMBL19780350 | 0.73 | KDM4E (0.62) | KDM4EALDH1A1HSD17B10CYP1A2CDC25B | |
| SCHEMBL3681837 | 0.73 | TSHR (0.68) | KDM4ETSHRALDH1A1HSD17B10CYP1A2 | |
| SCHEMBL19100359 | 0.72 | METTL3 (0.58) | KDM4ETSHRALDH1A1HSD17B10CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784182-A1 | 2-SULFANYL-BENZIMIDAZOL-1-YL-ACETIC ACID DERIVATIVES AS CRTH2 ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2007-05-16 | — | — | EP | disclosed |
| WO-2006021418-A1 | 2-SULFANYL-BENZOIMIDAZOL-1-YL-ACETIC ACID DERIVATIVES AS CRTH2 ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2006-03-02 | — | — | WO | disclosed |