Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | TDO2 | P48775 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 3/20 | 0.38 |
| ▸ | MMP2 | P08253 | 2/20 | 0.38 |
| ▸ | MMP14 | P50281 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6765900 | 0.86 | KDM4E (0.53) | MAPK10KDM4ENPC1PPARGNCOA2 | |
| SCHEMBL14487026 | 0.80 | IDO1 (0.44) | MAPK10IDO1TDO2ALDH1A1HPGD | |
| SCHEMBL8163621 | 0.76 | LMNA (0.49) | ALDH1A1SMN1; SMN2TSHRTP53ALOX12 | |
| SCHEMBL8162436 | 0.75 | TP53 (0.62) | KDM4EALDH1A1SMN1; SMN2TSHRTP53 | |
| SCHEMBL6172510 | 0.74 | SMN1; SMN2 (0.62) | KDM4EALDH1A1SMN1; SMN2TSHRTP53 | |
| SCHEMBL5744947 | 0.73 | RAB9A (0.52) | KDM4ENPC1ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL5376137 | 0.72 | SMN1; SMN2 (0.39) | KDM4EALDH1A1SMN1; SMN2TP53MAPK1 | |
| SCHEMBL3831656 | 0.71 | ALDH1A1 (0.50) | KDM4EALDH1A1SMN1; SMN2TSHRTP53 | |
| SCHEMBL3830480 | 0.71 | MAPT (0.46) | IDO1TDO2NPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6041578 | 0.68 | CA12 (0.51) | KDM4ENPC1ALDH1A1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235575-B2 | Guanidine mimics as factor Xa inhibitors | BRISTOL MYERS SQUIBB COMPANY (US) | 2007-06-26 | — | — | US | disclosed |
| US-7235575-B2 | Guanidine mimics as factor Xa inhibitors | BRISTOL MYERS SQUIBB COMPANY (US) | 2007-06-26 | — | — | US | disclosed |
| EP-0991638-A1 | NOVEL GUANIDINE MIMICS AS FACTOR Xa INHIBITORS | Du Pont Pharmaceuticals Company (US) | 2000-04-12 | — | — | EP | disclosed |
| WO-1998057951-A1 | NOVEL GUANIDINE MIMICS AS FACTOR Xa INHIBITORS | DU PONT PHARMACEUTICALS COMPANY (US) | 1998-12-23 | — | — | WO | disclosed |