Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | CASP3 | P42574 | 1/20 | 0.64 |
| ▸ | ATM | Q13315 | 1/20 | 0.64 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.64 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.64 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 6/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | AR | P10275 | 1/20 | 0.54 |
| ▸ | CBR1 | P16152 | 1/20 | 0.54 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | IDO1 | P14902 | 1/20 | 0.51 |
| ▸ | RORC | P51449 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL734813 | 0.84 | CYP1A2 (0.59) | NPC1POLBCASP3ATMSENP8 | |
| SCHEMBL5054132 | 0.83 | NPC1 (0.66) | NPC1POLBCASP3ATMSENP8 | |
| SCHEMBL733479 | 0.82 | ALDH1A1 (0.69) | NPC1POLBCASP3ATMSENP8 | |
| SCHEMBL30726102 | 0.81 | CYP1A2 (0.74) | NPC1POLBCASP3ATMSENP8 | |
| SCHEMBL28015342 | 0.81 | CYP1A2 (0.74) | NPC1POLBCASP3ATMSENP8 | |
| SCHEMBL732543 | 0.81 | CYP1A2 (0.59) | NPC1POLBCASP3ATMSENP8 | |
| SCHEMBL733344 | 0.80 | POLB (0.66) | NPC1POLBCASP3ATMSENP8 | |
| SCHEMBL733872 | 0.79 | CYP2C19 (0.58) | NPC1POLBCASP3ATMSENP8 | |
| SCHEMBL734843 | 0.79 | FADS1 (0.61) | NPC1POLBCASP3ATMSENP8 | |
| SCHEMBL733243 | 0.79 | CYP1A2 (0.58) | NPC1POLBCASP3ATMSENP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138195-B2 | Inhibitors of human phosphatidylinositol 3-kinase delta | ICOS CORPORATION (US) | 2012-03-20 | — | — | US | disclosed |
| EP-1278748-B1 | INHIBITORS OF HUMAN PHOSPHATIDYL-INOSITOL 3-KINASE DELTA | ICOS CORP (US) | 2011-03-23 | — | — | EP | disclosed |