Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMP1 | P13497 | 2/20 | 0.65 |
| ▸ | MMP8 | P22894 | 8/20 | 0.55 |
| ▸ | MMP13 | P45452 | 8/20 | 0.55 |
| ▸ | MMP1 | P03956 | 7/20 | 0.52 |
| ▸ | MMP3 | P08254 | 7/20 | 0.52 |
| ▸ | MMP7 | P09237 | 7/20 | 0.52 |
| ▸ | MMP9 | P14780 | 7/20 | 0.52 |
| ▸ | MMP2 | P08253 | 6/20 | 0.52 |
| ▸ | STS | P08842 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | YAP1 | P46937 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.44 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7348074 | 1.00 | BMP1 (0.65) | BMP1MMP8MMP13MMP1MMP3 | |
| Hydrochloric Acid SCHEMBL7348358 | 0.99 | BMP1 (0.64) | BMP1MMP8MMP13MMP1MMP3 | |
| SCHEMBL7354369 | 0.89 | MMP13 (0.52) | BMP1MMP8MMP13MMP1MMP3 | |
| SCHEMBL7354374 | 0.87 | MMP13 (0.53) | BMP1MMP8MMP13MMP1MMP3 | |
| SCHEMBL7354377 | 0.87 | MMP13 (0.53) | BMP1MMP8MMP13MMP1MMP3 | |
| SCHEMBL7355697 | 0.84 | BMP1 (0.59) | BMP1MMP8MMP13MMP1MMP3 | |
| SCHEMBL7355702 | 0.84 | BMP1 (0.59) | BMP1MMP8MMP13MMP1MMP3 | |
| SCHEMBL7350312 | 0.83 | TAS2R14 (0.48) | BMP1MMP8MMP13MMP1MMP3 | |
| SCHEMBL7350974 | 0.83 | TAS2R14 (0.48) | BMP1MMP8MMP13MMP1MMP3 | |
| SCHEMBL7350309 | 0.83 | TAS2R14 (0.48) | BMP1MMP8MMP13MMP1MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0766672-B1 | ARYLSULFONAMIDO-SUBSTITUTED HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS | NOVARTIS AG (CH) | 2000-10-04 | — | — | EP | disclosed |
| EP-0606046-B1 | Arylsulfonamido-substituted hydroxamic acids | CIBA GEIGY AG (CH) | 1997-10-08 | — | — | EP | disclosed |
| US-5646167-A | ADMINISTERED AS METALLOPROTEINASE INHIBITOR, ANTITUMOR OR ANTICARCINOGENIC AGENT | CIBA-GEIGY CORPORATION (US) | 1997-07-08 | — | — | US | disclosed |
| EP-0766672-A1 | ARYLSULFONAMIDO-SUBSTITUTED HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS | Novartis AG (CH) | 1997-04-09 | — | — | EP | disclosed |
| US-5552419-A | METALLOPROTEINASE INHIBITORS | CIBA-GEIGY CORPORATION (US) | 1996-09-03 | — | — | US | disclosed |
| US-5506242-A | METALLOELASTASE INHIBITOR; TREATS EMPHYSEMA | CIBA-GEIGY CORPORATION (US) | 1996-04-09 | — | — | US | disclosed |
| WO-1996000214-A1 | ARYLSULFONAMIDO-SUBSTITUTED HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS | CIBA-GEIGY AG (CH) | 1996-01-04 | — | — | WO | disclosed |
| EP-0606046-A1 | Arylsulfonamido-substituted hydroxamic acids | CIBA-GEIGY AG (CH) | 1994-07-13 | — | — | EP | disclosed |