Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | COMT | P21964 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6339999 | 0.95 | ALDH1A1 (0.49) | ALDH1A1KMT2ASMN1; SMN2PTGDR2RECQL | |
| SCHEMBL6403255 | 0.82 | SMN1; SMN2 (0.50) | ALDH1A1KMT2ASMN1; SMN2PTGDR2MAPK1 | |
| SCHEMBL6338203 | 0.80 | SMN1; SMN2 (0.60) | ALDH1A1KMT2ASMN1; SMN2PTGDR2MAPK1 | |
| SCHEMBL14124978 | 0.75 | MAPK1 (0.57) | ALDH1A1KMT2ASMN1; SMN2TDP1MAPK1 | |
| SCHEMBL9912563 | 0.71 | MAPK1 (0.47) | ALDH1A1KMT2ASMN1; SMN2TDP1MAPK1 | |
| SCHEMBL6995149 | 0.70 | SMN1; SMN2 (0.52) | ALDH1A1KMT2ASMN1; SMN2LMNAHTT | |
| SCHEMBL6995156 | 0.67 | SMN1; SMN2 (0.51) | ALDH1A1KMT2ASMN1; SMN2LMNAHTT | |
| SCHEMBL8205572 | 0.66 | SMN1; SMN2 (0.69) | ALDH1A1KMT2ASMN1; SMN2MAPK1LMNA | |
| SCHEMBL7000260 | 0.66 | SMN1; SMN2 (0.52) | ALDH1A1KMT2ASMN1; SMN2MAPK1LMNA | |
| SCHEMBL6338207 | 0.65 | ALDH1A1 (0.44) | ALDH1A1KMT2ASMN1; SMN2PTGDR2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0977756-A1 | PYRAZOLOPYRIMIDINONES WHICH INHIBIT TYPE 5 CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE PHOSPHODIESTERASE (cGMP PDE5) FOR THE TREATMENT OF SEXUAL DYSFUNCTION | Pfizer Limited (GB) | 2000-02-09 | — | — | EP | disclosed |
| WO-1998049166-A1 | PYRAZOLOPYRIMIDINONES WHICH INHIBIT TYPE 5 CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE PHOSPHODIESTERASE (cGMP PDE5) FOR THE TREATMENT OF SEXUAL DYSFUNCTION | PFIZER LIMITED (GB) | 1998-11-05 | — | — | WO | disclosed |