Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 6/20 | 0.51 |
| ▸ | MMP1 | P03956 | 5/20 | 0.51 |
| ▸ | MMP9 | P14780 | 3/20 | 0.51 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.50 |
| ▸ | MMP8 | P22894 | 2/20 | 0.49 |
| ▸ | CXCR3 | P49682 | 3/20 | 0.48 |
| ▸ | MMP2 | P08253 | 3/20 | 0.48 |
| ▸ | MMP3 | P08254 | 3/20 | 0.48 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.48 |
| ▸ | BMP1 | P13497 | 3/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.47 |
| ▸ | PTGES | O14684 | 1/20 | 0.47 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MMP7 | P09237 | 2/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7347667 | 0.88 | MMP13 (0.51) | MMP13MMP1MMP9TAS2R14MMP8 | |
| SCHEMBL7350309 | 0.81 | TAS2R14 (0.48) | MMP13MMP1MMP9TAS2R14MMP8 | |
| SCHEMBL7350312 | 0.81 | TAS2R14 (0.48) | MMP13MMP1MMP9TAS2R14MMP8 | |
| SCHEMBL7350974 | 0.81 | TAS2R14 (0.48) | MMP13MMP1MMP9TAS2R14MMP8 | |
| SCHEMBL7357097 | 0.80 | BMP1 (0.49) | MMP13MMP1MMP9MMP8MMP2 | |
| SCHEMBL7357102 | 0.80 | BMP1 (0.49) | MMP13MMP1MMP9MMP8MMP2 | |
| Hydrochloric Acid SCHEMBL7355757 | 0.80 | TAS2R14 (0.48) | MMP13MMP1MMP9TAS2R14MMP8 | |
| SCHEMBL6808879 | 0.80 | MMP13 (0.58) | MMP13MMP1MMP9TAS2R14MMP8 | |
| SCHEMBL7347776 | 0.79 | MMP13 (0.54) | MMP13MMP1MMP9TAS2R14MMP8 | |
| SCHEMBL7347774 | 0.79 | MMP13 (0.54) | MMP13MMP1MMP9TAS2R14MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0766672-B1 | ARYLSULFONAMIDO-SUBSTITUTED HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS | NOVARTIS AG (CH) | 2000-10-04 | — | — | EP | disclosed |
| US-5672615-A | MATRIX-DEGRADING METALLOPROTEINASE INHIBITORS | NOVARTIS CORPORATION (US) | 1997-09-30 | — | — | US | disclosed |
| US-5646167-A | ADMINISTERED AS METALLOPROTEINASE INHIBITOR, ANTITUMOR OR ANTICARCINOGENIC AGENT | CIBA-GEIGY CORPORATION (US) | 1997-07-08 | — | — | US | disclosed |
| EP-0766672-A1 | ARYLSULFONAMIDO-SUBSTITUTED HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS | Novartis AG (CH) | 1997-04-09 | — | — | EP | disclosed |
| US-5552419-A | METALLOPROTEINASE INHIBITORS | CIBA-GEIGY CORPORATION (US) | 1996-09-03 | — | — | US | disclosed |
| US-5506242-A | METALLOELASTASE INHIBITOR; TREATS EMPHYSEMA | CIBA-GEIGY CORPORATION (US) | 1996-04-09 | — | — | US | disclosed |
| WO-1996000214-A1 | ARYLSULFONAMIDO-SUBSTITUTED HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS | CIBA-GEIGY AG (CH) | 1996-01-04 | — | — | WO | disclosed |