Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.68 |
| ▸ | NPC1 | O15118 | 2/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.41 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7350319 | 0.81 | AVPR2 (0.64) | RAB9ANPC1ALDH1A1HPGDAVPR2 | |
| SCHEMBL7345789 | 0.80 | AVPR2 (0.50) | RAB9ANPC1L3MBTL1MAPTHSD17B3 | |
| SCHEMBL7351009 | 0.80 | HPGD (0.57) | RAB9ANPC1MAPTHPGDKMT2A | |
| SCHEMBL7352783 | 0.79 | L3MBTL1 (0.83) | RAB9ANPC1L3MBTL1ALDH1A1MAPT | |
| SCHEMBL7352773 | 0.79 | RAB9A (0.48) | RAB9ANPC1L3MBTL1ALDH1A1HPGD | |
| SCHEMBL7349938 | 0.78 | LMNA (0.53) | RAB9ANPC1ALDH1A1HSD17B3HPGD | |
| SCHEMBL2033421 | 0.76 | L3MBTL1 (0.64) | RAB9ANPC1L3MBTL1ALDH1A1MAPT | |
| SCHEMBL7352132 | 0.76 | PDE4A (0.57) | RAB9ANPC1ALDH1A1HPGDAVPR2 | |
| SCHEMBL7352814 | 0.74 | AVPR2 (0.68) | RAB9ANPC1ALDH1A1HPGDAVPR2 | |
| SCHEMBL7351890 | 0.72 | AVPR1A (0.72) | AVPR2AVPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5985869-A | USEFUL AS VASODILATORS, HYPOTENSIVE AGENTS, WATER DIURETICS, PLATELET AGGLUTINATION INHIBITORS | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1999-11-16 | — | — | US | disclosed |
| US-5753677-A | Benzoheterocyclic compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1998-05-19 | — | — | US | disclosed |
| US-5559230-A | VASOPRESSIN ANTAGONISTS, QUINOLINES, BENZAZEPINES, VASODILATION, HYPOTENSIVE AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-09-24 | — | — | US | disclosed |
| EP-0450097-B1 | BENZOHETEROCYCLIC COMPOUNDS | OTSUKA PHARMA CO LTD (JP) | 1996-04-24 | — | — | EP | disclosed |
| EP-0450097-A1 | BENZOHETEROCYCLIC COMPOUNDS. | OTSUKA PHARMA CO LTD (JP) | 1991-10-09 | — | — | EP | disclosed |
| WO-1991005549-A1 | BENZOHETEROCYCLIC COMPOUNDS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-05-02 | — | — | WO | disclosed |