Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 3/20 | 0.54 |
| ▸ | GABRD | O14764 | 3/20 | 0.54 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.54 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.54 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.54 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.54 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.54 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.54 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.54 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.54 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.54 |
| ▸ | GABRE | P78334 | 3/20 | 0.54 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.54 |
| ▸ | GABRG1 | Q8N1C3 | 3/20 | 0.54 |
| ▸ | GABRG3 | Q99928 | 3/20 | 0.54 |
| ▸ | GABRQ | Q9UN88 | 3/20 | 0.54 |
| ▸ | ENPEP | Q07075 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7353965 | 1.00 | GABRP (0.54) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL1427397 | 1.00 | GABRP (0.54) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL26547294 | 0.93 | ALDH1A1 (0.55) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL11515287 | 0.91 | ALDH1A1 (0.58) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL4037012 | 0.86 | GABRP (0.65) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL932317 | 0.86 | GABRP (0.65) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL288345 | 0.86 | GABRP (0.65) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL27963271 | 0.85 | ENPEP (0.60) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL1354935 | 0.81 | GABRP (0.73) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL18222603 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5599973-A | REACTING ACID CHLORIDE WITH SUBSTITUTED 2-OXAZOLIDINONE AND BUTYLLITHIUM, THEN BENZYL ALPHA-BROMOACETATE, HYDROGEN PEROXIDE, LITHIUM OXIDE, SODIUM METABISULFITE, BORANE DIMETHYL SULFIDE, THEN TOSYLATION, AZIDE FORMATION, AMINATION | NORTHWESTERN UNIVERSITY (US) | 1997-02-04 | — | — | US | disclosed |
| US-5563175-A | GAMMAAMINOBUTYRIC ACID DERIVATIVE; NERVOUS SYSTEM DISORDERS | NORTHWESTERN UNIVERSITY (US) | 1996-10-08 | — | — | US | disclosed |