Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.33 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | MYC | P01106 | 1/20 | 0.31 |
| ▸ | ELANE | P08246 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL576279 | 0.87 | L3MBTL1 (0.45) | LMNAHTTNPSR1L3MBTL1MAOA | |
| Hydrochloric Acid SCHEMBL28211399 | 0.85 | L3MBTL1 (0.44) | LMNAHTTNPSR1L3MBTL1MAOA | |
| SCHEMBL7359510 | 0.84 | GRM1 (0.47) | MAOAMAOB | |
| SCHEMBL575938 | 0.82 | LMNA (0.31) | LMNA | |
| SCHEMBL7361013 | 0.78 | CYP3A4 (0.51) | NPSR1ALDH1A1KMT2A | |
| SCHEMBL4470421 | 0.78 | HTT (0.38) | LMNAHTTNPSR1L3MBTL1MAOA | |
| SCHEMBL576739 | 0.78 | L3MBTL1 (0.42) | LMNAHTTNPSR1L3MBTL1MAOA | |
| SCHEMBL577037 | 0.76 | LMNA (0.41) | LMNAHTTNPSR1L3MBTL1MAOA | |
| SCHEMBL7357694 | 0.76 | GRM1 (0.46) | MAOAMAOB | |
| Hydrocinnamyl Alcohol SCHEMBL28050024 | 0.75 | NAAA (0.39) | LMNAHTTNPSR1L3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999036419-A1 | SUBSTITUTED LACTONES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | BAYER AKTIENGESELLSCHAFT (DE) | 1999-07-22 | — | — | WO | claimed |
| EP-1047686-A1 | SUBSTITUTED BICYCLIC LACTONES | Bayer Aktiengesellschaft (DE) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999036419-A1 | SUBSTITUTED LACTONES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | BAYER AKTIENGESELLSCHAFT (DE) | 1999-07-22 | — | — | WO | disclosed |
| WO-1999036418-A1 | SUBSTITUTED BICYCLIC LACTONES | BAYER AKTIENGESELLSCHAFT (DE) | 1999-07-22 | — | — | WO | disclosed |