SCHEMBL7350494

SCHEMBL7350494

COc1ccc2c(c1)=CC(=O)N=2

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 8/20 0.37
HPGD P15428 5/20 0.37
KDM4E B2RXH2 5/20 0.37
NPC1 O15118 4/20 0.37
RAB9A P51151 4/20 0.37
SMN1; SMN2 Q16637 3/20 0.37
MAPT P10636 2/20 0.37
ERN1 O75460 1/20 0.37
CASP3 P42574 1/20 0.37
SENP8 Q96LD8 1/20 0.37
SENP7 Q9BQF6 1/20 0.37
SENP6 Q9GZR1 1/20 0.37
GSTP1 P09211 1/20 0.37
CA1 P00915 4/20 0.36
CA7 P43166 4/20 0.36
CA9 Q16790 4/20 0.36
CA12 O43570 3/20 0.36
CA2 P00918 3/20 0.36
CA14 Q9ULX7 3/20 0.36
BACE1 P56817 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6854794 0.85 ALOX5 (0.37) ALDH1A1HPGDKDM4ENPC1RAB9A
Phenylacetylene SCHEMBL29291652 0.84 ALDH1A1 (0.36) ALDH1A1HPGDKDM4ENPC1RAB9A
SCHEMBL21561708 0.75 ALDH1A1 (0.43) ALDH1A1HPGDKDM4ENPC1RAB9A
SCHEMBL31588945 0.73 GRIN2D (0.36) ALDH1A1HPGDKDM4ESMN1; SMN2MAPT
SCHEMBL7347464 0.73 TOP1 (0.49) NPC1GSTP1CA1CA7CA9
SCHEMBL28793403 0.73 CA1 (0.46) ALDH1A1HPGDKDM4ESMN1; SMN2MAPT
SCHEMBL1152547 0.72 CA1 (0.42) ALDH1A1HPGDKDM4ENPC1RAB9A
SCHEMBL7839823 0.72 EGFR (0.36) RAB9ACYP1A2LMNAKMT2A
SCHEMBL1315934 0.71 KDM4E (0.32) ALDH1A1HPGDKDM4ECA1CA7
SCHEMBL14854684 0.71 HSP90AA1 (0.35) HPGDCA1CA7CA9CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114539121-A A novel, photo-promoted process for the preparation of sulfonates and sulfonamides from sulfonyl chlorides 天津师范大学 2022-05-27 CN claimed
CN-119371391-A Aroyl compound and preparation method and application thereof 河北医科大学 2025-01-28 CN disclosed
CN-115073353-B Lignan derivative, preparation method thereof, pharmaceutical composition and application thereof 中国医学科学院药物研究所 2024-05-14 CN disclosed
CN-117794529-A POLO-like kinase 4 inhibitors 欧瑞克制药公司 2024-03-29 CN disclosed
CN-109988093-B Amine compound for inhibiting SSAO/VAP-1 and application thereof in medicine 广东东阳光药业有限公司 2023-04-07 CN disclosed
CN-115073353-A Lignan derivative and preparation method, pharmaceutical composition and application thereof 中国医学科学院药物研究所 2022-09-20 CN disclosed
WO-2022184049-A1 PLK4 INHIBITOR AND USE THEREOF 上海齐鲁制药研究中心有限公司 2022-09-09 WO disclosed
CN-114539121-A A novel, photo-promoted process for the preparation of sulfonates and sulfonamides from sulfonyl chlorides 天津师范大学 2022-05-27 CN disclosed
EP-0581939-B1 N-SULPHONYL-2-OXOINDOLE DERIVATIVES HAVING AFFINITY FOR VASOPRESSIN AND/OR OCYTOCIN RECEPTORS SANOFI SA (FR) 1999-06-02 EP disclosed
EP-0581939-A1 N-SULPHONYL-2-OXOINDOLE DERIVATIVES HAVING AFFINITY FOR VASOPRESSIN AND/OR OCYTOCIN RECEPTORS SANOFI (FR) 1994-02-09 EP disclosed
WO-1993015051-A1 N-SULPHONYL-2-OXOINDOLE DERIVATIVES HAVING AFFINITY FOR VASOPRESSIN AND/OR OCYTOCIN RECEPTORS ELF SANOFI (FR) 1993-08-05 WO disclosed